Title |
Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat
|
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Published in |
Scientific Data, July 2014
|
DOI | 10.1038/sdata.2014.17 |
Pubmed ID | |
Authors |
Katrina J Falkenberg, Cathryn M Gould, Ricky W Johnstone, Kaylene J Simpson |
Abstract |
Identification of mechanisms of resistance to histone deacetylase inhibitors, such as vorinostat, is important in order to utilise these anticancer compounds more efficiently in the clinic. Here, we present a dataset containing multiple tiers of stringent siRNA screening for genes that when knocked down conferred sensitivity to vorinostat-induced cell death. We also present data from a miRNA overexpression screen for miRNAs contributing to vorinostat sensitivity. Furthermore, we provide transcriptomic analysis using massively parallel sequencing upon knockdown of 14 validated vorinostat-resistance genes. These datasets are suitable for analysis of genes and miRNAs involved in cell death in the presence and absence of vorinostat as well as computational biology approaches to identify gene regulatory networks. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Greece | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 41 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 26% |
Researcher | 11 | 26% |
Other | 4 | 9% |
Student > Bachelor | 3 | 7% |
Professor > Associate Professor | 2 | 5% |
Other | 5 | 12% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 37% |
Biochemistry, Genetics and Molecular Biology | 8 | 19% |
Computer Science | 4 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Medicine and Dentistry | 2 | 5% |
Other | 4 | 9% |
Unknown | 7 | 16% |