Title |
Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia
|
---|---|
Published in |
Pediatric Surgery International, July 2014
|
DOI | 10.1007/s00383-014-3549-z |
Pubmed ID | |
Authors |
Florian Friedmacher, Naho Fujiwara, Alejandro Daniel Hofmann, Hiromizu Takahashi, Jan-Hendrik Gosemann, Prem Puri |
Abstract |
Pulmonary hypoplasia (PH) is a serious condition in newborns with congenital diaphragmatic hernia (CDH). Lipid-containing interstitial fibroblasts (LIFs) play an essential role in fetal lung maturation by stimulating alveolarization and lipid homeostasis. In rodents, LIFs are first evident during the canalicular phase of lung development with a significant increase over the last 4 days of gestation. Adipocyte differentiation-related protein (ADRP), a functional lipogenic molecular marker characterizing LIFs, is highly expressed in fetal lungs during this critical time period. We hypothesized that LIF expression in hypoplastic rat lungs is decreased in the nitrofen-induced CDH model, which is accompanied by reduced alveolar ADRP expression and lipid content. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 21% |
Student > Master | 3 | 16% |
Student > Bachelor | 2 | 11% |
Researcher | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Other | 4 | 21% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 37% |
Agricultural and Biological Sciences | 5 | 26% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Chemistry | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 16% |