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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Global Programmed Switch in Neural Daughter Cell Proliferation Mode Triggered by a Temporal Gene Cascade
|
|---|---|
| Published in |
Developmental Cell, July 2014
|
| DOI | 10.1016/j.devcel.2014.06.021 |
| Pubmed ID | |
| Authors |
Magnus Baumgardt, Daniel Karlsson, Behzad Y. Salmani, Caroline Bivik, Ryan B. MacDonald, Erika Gunnar, Stefan Thor |
| Abstract |
During central nervous system (CNS) development, progenitors typically divide asymmetrically, renewing themselves while budding off daughter cells with more limited proliferative potential. Variation in daughter cell proliferation has a profound impact on CNS development and evolution, but the underlying mechanisms remain poorly understood. We find that Drosophila embryonic neural progenitors (neuroblasts) undergo a programmed daughter proliferation mode switch, from generating daughters that divide once (type I) to generating neurons directly (type 0). This typeI>0 switch is triggered by activation of Dacapo (mammalian p21(CIP1)/p27(KIP1)/p57(Kip2)) expression in neuroblasts. In the thoracic region, Dacapo expression is activated by the temporal cascade (castor) and the Hox gene Antennapedia. In addition, castor, Antennapedia, and the late temporal gene grainyhead act combinatorially to control the precise timing of neuroblast cell-cycle exit by repressing Cyclin E and E2f. This reveals a logical principle underlying progenitor and daughter cell proliferation control in the Drosophila CNS. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Portugal | 2 | 2% |
| Unknown | 105 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 28% |
| Researcher | 25 | 23% |
| Student > Bachelor | 10 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Student > Postgraduate | 6 | 6% |
| Other | 13 | 12% |
| Unknown | 19 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 40% |
| Biochemistry, Genetics and Molecular Biology | 33 | 30% |
| Neuroscience | 9 | 8% |
| Medicine and Dentistry | 2 | 2% |
| Chemistry | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 20 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2017.
All research outputs
#4,599,765
of 25,373,627 outputs
Outputs from Developmental Cell
#1,788
of 4,318 outputs
Outputs of similar age
#42,396
of 242,345 outputs
Outputs of similar age from Developmental Cell
#21
of 65 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,318 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.0. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,345 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.