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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation
|
|---|---|
| Published in |
Nanomedicine: Nanotechnology, Biology and Medicine, September 2014
|
| DOI | 10.1016/j.nano.2014.08.009 |
| Pubmed ID | |
| Authors |
Ankit Mittal, Kai Schulze, Thomas Ebensen, Sebastian Weißmann, Steffi Hansen, Claus Michael Lehr, Carlos A. Guzmán |
| Abstract |
Trans-follicular (TF) vaccination has recently been studied as a unique route for non-invasive transcutaneous vaccination. The present study aims to extensively characterize the immune responses triggered by TF vaccination using ovalbumin loaded chitosan-PLGA (poly lactic-co-glycolic acid) nanoparticles without skin pre-treatment to preserve skin integrity. The impact of formulation composition i.e. antigenic solution or antigen-loaded nanoparticles with or without adjuvant [bis-(3',5')-cyclic dimeric adenosine monophosphate] on immune response quality following TF immunization was analyzed and compared with immune responses obtained after tape stripping the skin. The results presented in this study confirm the ability of nanoparticle based vaccine formulations to deliver antigen across the intact skin via the follicular route, but at the same time demonstrate the necessity to include adjuvants to generate efficient antigen-specific humoral and cellular immune responses. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 2% |
| Germany | 1 | 2% |
| Australia | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 57 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 18% |
| Student > Master | 9 | 15% |
| Student > Ph. D. Student | 7 | 11% |
| Professor | 5 | 8% |
| Student > Doctoral Student | 5 | 8% |
| Other | 10 | 16% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 18% |
| Agricultural and Biological Sciences | 9 | 15% |
| Medicine and Dentistry | 7 | 11% |
| Engineering | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Other | 12 | 20% |
| Unknown | 16 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2020.
All research outputs
#1,025,831
of 25,371,288 outputs
Outputs from Nanomedicine: Nanotechnology, Biology and Medicine
#39
of 1,520 outputs
Outputs of similar age
#10,401
of 250,094 outputs
Outputs of similar age from Nanomedicine: Nanotechnology, Biology and Medicine
#2
of 18 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,520 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,094 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.