| Title |
Developmental Exposure to Pesticides Alters Motor Activity and Coordination in Rats: Sex Differences and Underlying Mechanisms
|
|---|---|
| Published in |
Neurotoxicity Research, October 2017
|
| DOI | 10.1007/s12640-017-9823-9 |
| Pubmed ID | |
| Authors |
B. Gómez-Giménez, V. Felipo, A. Cabrera-Pastor, A. Agustí, V. Hernández-Rabaza, M. Llansola |
| Abstract |
It has been proposed that developmental exposure to pesticides contributes to increasing prevalence of neurodevelopmental disorders in children, such as attention deficit with hyperactivity (ADHD) and to alterations in coordination skills. However, the mechanisms involved in these alterations remain unclear. We analyzed the effects on spontaneous motor activity and motor coordination of developmental exposure to a representative pesticide of each one of the four main chemical families: organophosphates (chlorpyrifos), carbamates (carbaryl), organochlorines (endosulfan), and pyrethroids (cypermethrin). Pesticides were administered once a day orally, in a sweet jelly, from gestational day 7 to post natal day 21. Spontaneous motor activity was assessed by an actimeter and motor coordination using the rotarod, when rats were adults. The effects were analyzed separately in males and females. Extracellular GABA in cerebellum and NMDA receptor subunits in hippocampus were assessed as possible underlying mechanisms of motor alterations. Motor coordination was impaired by developmental exposure to endosulfan, cypermethrin, and chlorpyrifos in females but not in males. The effect of endosulfan and cypermethrin would be due to increased extracellular GABA in cerebellum, which remains unaltered in male rats. Chlorpyrifos increased motor activity in males and females. Cypermethrin decreased motor activity mainly in males. In male rats, but not in females, expression of the NR2B subunit of NMDA receptor in hippocampus correlated with motor activity. These results show sex-specific effects of different pesticides on motor activity and coordination, associated with neurotransmission alterations. These data contribute to better understand the relationship between developmental exposure to the main pesticide families and motor disorders in children. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 12% |
| Student > Master | 10 | 12% |
| Student > Bachelor | 8 | 10% |
| Unspecified | 7 | 8% |
| Student > Ph. D. Student | 6 | 7% |
| Other | 19 | 23% |
| Unknown | 23 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Medicine and Dentistry | 7 | 8% |
| Unspecified | 7 | 8% |
| Neuroscience | 6 | 7% |
| Other | 20 | 24% |
| Unknown | 28 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 192. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2021.
All research outputs
#172,856
of 23,005,189 outputs
Outputs from Neurotoxicity Research
#2
of 886 outputs
Outputs of similar age
#4,080
of 323,064 outputs
Outputs of similar age from Neurotoxicity Research
#1
of 31 outputs
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