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Reprogramming Microbial Metabolic Pathways

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Cover of 'Reprogramming Microbial Metabolic Pathways'

Table of Contents

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    Book Overview
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    Chapter 1 Towards Synthetic Gene Circuits with Enhancers: Biology's Multi-input Integrators.
  3. Altmetric Badge
    Chapter 2 Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways
  4. Altmetric Badge
    Chapter 3 Evolutionary Engineering for Industrial Microbiology
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    Chapter 4 Monitoring microbial diversity of bioreactors using metagenomic approaches.
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    Chapter 5 Synthetic biology triggers new era of antibiotics development.
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    Chapter 6 Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis
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    Chapter 7 Systems analysis of microbial adaptations to simultaneous stresses.
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    Chapter 8 Metabolic Reprogramming Under Microaerobic and Anaerobic Conditions in Bacteria
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    Chapter 9 Tunable promoters in synthetic and systems biology.
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    Chapter 10 Analysis of Corynebacterium glutamicum Promoters and Their Applications
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    Chapter 11 Production of Fumaric Acid by Fermentation
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    Chapter 12 Metabolic Engineering of Microorganisms for Vitamin C Production
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    Chapter 13 Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum
  15. Altmetric Badge
    Chapter 14 Microbial Metabolic Engineering for L-Threonine Production
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    Chapter 15 The Production of Coenzyme Q10 in Microorganisms
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    Chapter 16 Genetic Modification and Bioprocess Optimization for S-Adenosyl-L-methionine Biosynthesis
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    Chapter 17 Manipulation of Ralstonia eutropha Carbon Storage Pathways to Produce Useful Bio-Based Products
  19. Altmetric Badge
    Chapter 18 Metabolic Engineering of Inducer Formation for Cellulase and Hemicellulase Gene Expression in Trichoderma reesei
  20. Altmetric Badge
    Chapter 19 Microbiologically produced carboxylic acids used as building blocks in organic synthesis.
Attention for Chapter 19: Microbiologically produced carboxylic acids used as building blocks in organic synthesis.
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Chapter title
Microbiologically produced carboxylic acids used as building blocks in organic synthesis.
Chapter number 19
Book title
Reprogramming Microbial Metabolic Pathways
Published in
Sub cellular biochemistry, January 2012
DOI 10.1007/978-94-007-5055-5_19
Pubmed ID
Book ISBNs
978-9-40-075054-8, 978-9-40-075055-5
Authors

Andreas Aurich, Robert Specht, Roland A Müller, Ulrich Stottmeister, Venelina Yovkova, Christina Otto, Martina Holz, Gerold Barth, Philipp Heretsch, Franziska A Thomas, Dieter Sicker, Athanassios Giannis, Roland A. Müller, Franziska A. Thomas

Abstract

Oxo- and hydroxy-carboxylic acids are of special interest in organic synthesis. However, their introduction by chemical reactions tends to be troublesome especially with regard to stereoselectivity. We describe herein the biotechnological preparation of selected oxo- and hydroxycarboxylic acids under "green" conditions and their use as promising new building blocks. Thereby, our biotechnological goal was the development of process fundamentals regarding the variable use of renewable raw materials, the development of a multi purpose bioreactor and application of a pilot plant with standard equipment for organic acid production to minimize the technological effort. Furthermore the development of new product isolation procedures, with the aim of direct product recovery, capture of products or single step operation, was necessary. The application of robust and approved microorganisms, also genetically modified, capable of using a wide range of substrates as well as producing a large spectrum of products, was of special importance. Microbiologically produced acids, like 2-oxo-glutaric acid and 2-oxo-D-gluconic acid, are useful educts for the chemical synthesis of hydrophilic triazines, spiro-connected heterocycles, benzotriazines, and pyranoic amino acids. The chiral intermediate of the tricarboxylic acid cycle, (2R,3S)-isocitric acid, is another promising compound. For the first time our process provides large quantities of enantiopure trimethyl (2R,3S)-isocitrate which was used in subsequent chemical transformations to provide new chiral entities for further usage in total synthesis and pharmaceutical research.Oxo- and hydroxy-carboxylic acids are of special interest in organic synthesis. However, their introduction by chemical reactions tends to be troublesome especially with regard to stereoselectivity. We describe herein the biotechnological preparation of selected oxo- and hydroxycarboxylic acids under "green" conditions and their use as promising new building blocks. Thereby, our biotechnological goal was the development of process fundamentals regarding the variable use of renewable raw materials, the development of a multi purpose bioreactor and application of a pilot plant with standard equipment for organic acid production to minimize the technological effort. Furthermore the development of new product isolation procedures, with the aim of direct product recovery, capture of products or single step operation, was necessary. The application of robust and approved microorganisms, also genetically modified, capable of using a wide range of substrates as well as producing a large spectrum of products, was of special importance. Microbiologically produced acids, like 2-oxo-glutaric acid and 2-oxo-D-gluconic acid, are useful educts for the chemical synthesis of hydrophilic triazines, spiro-connected heterocycles, benzotriazines, and pyranoic amino acids. The chiral intermediate of the tricarboxylic acid cycle, (2R,3S)-isocitric acid, is another promising compound. For the first time our process provides large quantities of enantiopure trimethyl (2R,3S)-isocitrate which was used in subsequent chemical transformations to provide new chiral entities for further usage in total synthesis and pharmaceutical research.

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Mendeley readers

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The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 26%
Researcher 4 21%
Student > Bachelor 3 16%
Student > Ph. D. Student 3 16%
Professor 1 5%
Other 1 5%
Unknown 2 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 26%
Chemical Engineering 4 21%
Agricultural and Biological Sciences 3 16%
Business, Management and Accounting 1 5%
Medicine and Dentistry 1 5%
Other 1 5%
Unknown 4 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2014.
All research outputs
#14,786,093
of 22,764,165 outputs
Outputs from Sub cellular biochemistry
#176
of 354 outputs
Outputs of similar age
#159,465
of 244,307 outputs
Outputs of similar age from Sub cellular biochemistry
#18
of 27 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 354 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.