| Title |
Cancer Risk Assessment Using Genetic Panel Testing: Considerations for Clinical Application
|
|---|---|
| Published in |
Journal of Genetic Counseling, March 2014
|
| DOI | 10.1007/s10897-014-9695-6 |
| Pubmed ID | |
| Authors |
Susan Hiraki, Erica S. Rinella, Freya Schnabel, Ruth Oratz, Harry Ostrer |
| Abstract |
With the completion of the Human Genome Project and the development of high throughput technologies, such as next-generation sequencing, the use of multiplex genetic testing, in which multiple genes are sequenced simultaneously to test for one or more conditions, is growing rapidly. Reflecting underlying heterogeneity where a broad range of genes confer risks for one or more cancers, the development of genetic cancer panels to assess these risks represents just one example of how multiplex testing is being applied clinically. There are a number of issues and challenges to consider when conducting genetic testing for cancer risk assessment, and these issues become exceedingly more complex when moving from the traditional single-gene approach to panel testing. Here, we address the practical considerations for clinical use of panel testing for breast, ovarian, and colon cancers, including the benefits, limitations and challenges, genetic counseling issues, and management guidelines. |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 5% |
| Unknown | 56 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 24% |
| Researcher | 10 | 17% |
| Student > Ph. D. Student | 7 | 12% |
| Professor > Associate Professor | 6 | 10% |
| Other | 5 | 8% |
| Other | 12 | 20% |
| Unknown | 5 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 34% |
| Biochemistry, Genetics and Molecular Biology | 13 | 22% |
| Agricultural and Biological Sciences | 10 | 17% |
| Social Sciences | 3 | 5% |
| Psychology | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 8 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2015.
All research outputs
#2,456,992
of 22,764,165 outputs
Outputs from Journal of Genetic Counseling
#108
of 1,141 outputs
Outputs of similar age
#26,238
of 221,179 outputs
Outputs of similar age from Journal of Genetic Counseling
#1
of 19 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,141 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,179 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.