Title |
Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection After Liver Transplantation: An Open-Label Study
|
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Published in |
Gastroenterology, September 2014
|
DOI | 10.1053/j.gastro.2014.09.023 |
Pubmed ID | |
Authors |
Michael P. Curry, Xavier Forns, Raymond T. Chung, Norah A. Terrault, Robert Brown, Jonathan M. Fenkel, Fredric Gordon, Jacqueline O’Leary, Alexander Kuo, Thomas Schiano, Gregory Everson, Eugene Schiff, Alex Befeler, Edward Gane, Sammy Saab, John G. McHutchison, G. Mani Subramanian, William T. Symonds, Jill Denning, Lindsay McNair, Sarah Arterburn, Evguenia Svarovskaia, Dilip Moonka, Nezam Afdhal |
Abstract |
Patients with detectable hepatitis C virus (HCV) RNA at the time of liver transplantation universally experience recurrent HCV infection. Antiviral treatment before transplantation can prevent HCV recurrence, but existing interferon-based regimens are poorly tolerated and are either ineffective or contraindicated in most patients. We performed a trial to determine whether sofosbuvir and ribavirin treatment before liver transplantation could prevent HCV recurrence afterward. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 21% |
United States | 2 | 14% |
Canada | 2 | 14% |
India | 1 | 7% |
United Kingdom | 1 | 7% |
Unknown | 5 | 36% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 71% |
Practitioners (doctors, other healthcare professionals) | 3 | 21% |
Scientists | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 1% |
Spain | 2 | 1% |
Colombia | 1 | <1% |
United States | 1 | <1% |
Unknown | 165 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 26 | 15% |
Student > Bachelor | 23 | 13% |
Researcher | 21 | 12% |
Student > Postgraduate | 21 | 12% |
Student > Master | 19 | 11% |
Other | 34 | 20% |
Unknown | 27 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 87 | 51% |
Agricultural and Biological Sciences | 11 | 6% |
Biochemistry, Genetics and Molecular Biology | 8 | 5% |
Nursing and Health Professions | 4 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 20 | 12% |
Unknown | 37 | 22% |