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Dynamics of telopodes (telocyte prolongations) in cell culture depends on extracellular matrix protein

Overview of attention for article published in Molecular and Cellular Biochemistry, September 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

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1 blog
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Citations

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40 Dimensions

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27 Mendeley
Title
Dynamics of telopodes (telocyte prolongations) in cell culture depends on extracellular matrix protein
Published in
Molecular and Cellular Biochemistry, September 2014
DOI 10.1007/s11010-014-2215-z
Pubmed ID
Authors

Cristina Mariana Niculite, T. M. Regalia, Mihaela Gherghiceanu, R. Huica, Mihaela Surcel, C. Ursaciuc, M. Leabu, L. M. Popescu

Abstract

Telocytes (TC) are cells with telopodes (Tp), very long prolongations (up to 100 μm) with an uneven caliber ( www.telocytes.com ). Factors determining the dynamics of cellular prolongations are still unknown, although previous studies showed telopode motility in TC cultures. We comparatively investigated, by time-lapse videomicroscopy, the dynamics of Tp of mouse heart TC seeded on collagen, fibronectin, and laminin. Under our experimental conditions, TC and fibroblasts (cell line L929) behaved differently in terms of adherence, spreading, and prolongation extension. Fibroblasts showed lower spreading on the matrix proteins used. The time needed for spreading was 2-4 h for TC, versus 8-10 h for fibroblasts. The values for final cell surface area after spreading were between 200 and 400 μm(2) for fibroblasts and 800-2,000 μm(2) for TC. TC showed a more than three times higher ability to spread on the tested matrix proteins. An extremely low capacity to extend prolongations with lengths shorter than cell bodies was noted for fibroblasts, while TC extended prolongations longer than the cell body length, with a moniliform appearance. The stronger adherence and spreading were noted for TC seeded on fibronectin, while the lowest were on laminin. Collagen determined an intermediate adherence and spreading for TC, but the highest dynamics in Tp extensions. In conclusion, TC behave differently than fibroblasts in terms of adherence, spreading, and cell prolongation extension when seeded on various matrix proteins in cell culture.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 4%
United States 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 22%
Student > Master 4 15%
Professor > Associate Professor 4 15%
Researcher 4 15%
Student > Bachelor 2 7%
Other 3 11%
Unknown 4 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 22%
Agricultural and Biological Sciences 5 19%
Medicine and Dentistry 4 15%
Veterinary Science and Veterinary Medicine 3 11%
Engineering 2 7%
Other 2 7%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2015.
All research outputs
#2,749,174
of 22,765,347 outputs
Outputs from Molecular and Cellular Biochemistry
#76
of 2,297 outputs
Outputs of similar age
#31,735
of 251,161 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#2
of 40 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,297 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,161 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.