Title |
Valproic acid-induced pancreatitis: 16 new cases and a review of the literature
|
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Published in |
Journal of Gastroenterology, February 2007
|
DOI | 10.1007/s00535-006-1961-4 |
Pubmed ID | |
Authors |
Thorsten Gerstner, Deike Büsing, Nellie Bell, Elke Longin, Johannes-Martin Kasper, Wolfgang Klostermann, Burkhard Hebing, Folker Hanefeld, Ulrich Eckel, Reiner Hoffmann, Ulrich Bettendorf, Birgit Weidner, Adelheid Wiemer-Kruel, Knut Brockmann, Fritz-Wilhelm Neumann, Thorsten Sandrieser, Markus Wolff, Stephan König |
Abstract |
Acute pancreatitis is rarely seen in children, and, in contrast to cases in adults, it is often drug induced. One possible medication is the antiepileptic drug valproic acid (VPA), which is commonly prescribed for generalized and focal epilepsy, migraine, neuropathic pain, and bipolar disorder. The common side effects associated with VPA are typically benign, but less common but more serious adverse effects may occur. These include hepatotoxicity, hyperammonemic encephalopathy, coagulation disorders, and pancreatitis. Since 1979, a few cases of pancreatitis induced by VPA have been published in the medical literature. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 7 | 15% |
Student > Postgraduate | 7 | 15% |
Researcher | 7 | 15% |
Student > Master | 4 | 9% |
Professor | 3 | 7% |
Other | 8 | 17% |
Unknown | 10 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 48% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Environmental Science | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 4% |
Unknown | 14 | 30% |