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Influence of lipoic acid on testicular toxicity induced by bi-n-butyl phthalate in rats

Overview of attention for article published in Food & Chemical Toxicology, June 2014
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Title
Influence of lipoic acid on testicular toxicity induced by bi-n-butyl phthalate in rats
Published in
Food & Chemical Toxicology, June 2014
DOI 10.1016/j.fct.2014.05.024
Pubmed ID
Authors

Hesham A. El-Beshbishy, Reham A. Mariah, Nevin M. Al-Azhary, Hamdy A.A. Aly, Hani A. Ozbak, Hussam H. Baghdadi

Abstract

Bi-n-butyl phthalate (BNBP) is an environmental pollutant. The aim of this study was to evaluate the protective effect of lipoic acid (LA) against testicular dysfunction associated with the intake of to BNBP- intoxicated rats. Adult male Wistar rats were divided into 4 groups of 6 animals each, and received medication orally for 14 days. Group I rats received 0.5 ml corn oil. Group II rats received LA (20 mg/kg B.W./day). Group III rats received BNBP (250 mg/kg B.W./day). Group IV rats received LA 24h prior to BNBP intake. Testes weight, cauda sperm count and sperm motility were decreased significantly by 18.15%, 13.83% and 13.5%, respectively, after BNBP treatment. Significant increase by 12.1%, 10.20% and 11.51%, respectively, was observed in LA-BNBP rats. Significant increase by 1.53%, 1.5% and 1.8%, for serum follicle stimulating hormone, testosterone and total antioxidant status, respectively, were observed in LA-BNBP rats. Testicular lipid peroxides and lactate dehydrogenase enzyme were significantly decreased by 1.5 and 1.6 folds, respectively, in LA-BNBP rats were decreased after BNBP treatment. Testicular superoxide dismutase, catalase and glutathione reductase enzymes were significantly increased in LA-BNBP rats. LA-BNBP rats, decreased the damage to seminiferous tubules produced by BNBP intake. In conclusion, LA mitigated BNBP-induced testicular toxicity through antioxidant mechanism and by direct free radical scavenging activity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 25%
Student > Doctoral Student 3 19%
Professor > Associate Professor 3 19%
Student > Ph. D. Student 2 13%
Other 1 6%
Other 2 13%
Unknown 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 38%
Environmental Science 4 25%
Medicine and Dentistry 2 13%
Biochemistry, Genetics and Molecular Biology 1 6%
Chemistry 1 6%
Other 1 6%
Unknown 1 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2014.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Food & Chemical Toxicology
#4,244
of 5,714 outputs
Outputs of similar age
#145,706
of 242,856 outputs
Outputs of similar age from Food & Chemical Toxicology
#36
of 51 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,714 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,856 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.