| Title |
T Cell Receptor Profiling in Type 1 Diabetes
|
|---|---|
| Published in |
Current Diabetes Reports, October 2017
|
| DOI | 10.1007/s11892-017-0946-4 |
| Pubmed ID | |
| Authors |
Laura M. Jacobsen, Amanda Posgai, Howard R. Seay, Michael J. Haller, Todd M. Brusko |
| Abstract |
The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with minor risk variants, have long been thought to shape the T cell receptor (TCR) repertoire and eventual phenotype of autoreactive T cells that mediate β-cell destruction. While autoantibodies provide robust markers of disease progression, early studies tracking autoreactive T cells largely failed to achieve clinical utility. Advances in acquisition of pancreata and islets from T1D organ donors have facilitated studies of T cells isolated from the target tissues. Immunosequencing of TCR α/β-chain complementarity determining regions, along with transcriptional profiling, offers the potential to transform biomarker discovery. Herein, we review recent studies characterizing the autoreactive TCR signature in T1D, emerging technologies, and the challenges and opportunities associated with tracking TCR molecular profiles during the natural history of T1D. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 102 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 22% |
| Student > Ph. D. Student | 17 | 17% |
| Student > Bachelor | 15 | 15% |
| Student > Postgraduate | 7 | 7% |
| Student > Master | 6 | 6% |
| Other | 13 | 13% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 19% |
| Immunology and Microbiology | 15 | 15% |
| Medicine and Dentistry | 12 | 12% |
| Agricultural and Biological Sciences | 11 | 11% |
| Engineering | 4 | 4% |
| Other | 14 | 14% |
| Unknown | 27 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2022.
All research outputs
#6,536,702
of 23,576,969 outputs
Outputs from Current Diabetes Reports
#328
of 1,024 outputs
Outputs of similar age
#104,383
of 325,540 outputs
Outputs of similar age from Current Diabetes Reports
#14
of 31 outputs
Altmetric has tracked 23,576,969 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,024 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.