| Title |
Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis
|
|---|---|
| Published in |
BMC Endocrine Disorders, October 2017
|
| DOI | 10.1186/s12902-017-0213-3 |
| Pubmed ID | |
| Authors |
Ahmadou M. Jingi, Aurel T. Tankeu, Narcisse Assene Ateba, Jean Jacques Noubiap |
| Abstract |
Insulin treatment has been associated with a paradoxical worsening of diabetes retinopathy since many years in European cohorts. Recently, this issue has been stressed by some studies conducted in other parts of the world. However, the mechanism underlying such evolution is not well understood. An osmotic theory has been evocated but failed to explain the clinical features of the disease. Considering recent findings from basic and clinical research, we discuss the possibility of a synergistic hypothesis based on the simultaneous action of insulin and vascular endothelial growth factor on eye blood vessels. We postulate that exogenous insulin could act synergistically with the vascular endothelial growth factor expressed by ischemic retina so as to trigger vascular proliferation and the worsening of diabetes retinopathy. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 30% |
| New Zealand | 1 | 5% |
| Saudi Arabia | 1 | 5% |
| India | 1 | 5% |
| Canada | 1 | 5% |
| Australia | 1 | 5% |
| United States | 1 | 5% |
| Unknown | 8 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 60% |
| Practitioners (doctors, other healthcare professionals) | 5 | 25% |
| Science communicators (journalists, bloggers, editors) | 2 | 10% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 76 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 11% |
| Student > Postgraduate | 8 | 11% |
| Student > Ph. D. Student | 8 | 11% |
| Other | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 9 | 12% |
| Unknown | 30 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 36% |
| Agricultural and Biological Sciences | 5 | 7% |
| Nursing and Health Professions | 4 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Engineering | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 33 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2023.
All research outputs
#1,669,377
of 25,657,205 outputs
Outputs from BMC Endocrine Disorders
#48
of 876 outputs
Outputs of similar age
#32,651
of 334,512 outputs
Outputs of similar age from BMC Endocrine Disorders
#1
of 8 outputs
Altmetric has tracked 25,657,205 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 876 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,512 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them