| Title |
miR-200b as a prognostic factor targets multiple members of RAB family in glioma
|
|---|---|
| Published in |
Medical Oncology, January 2014
|
| DOI | 10.1007/s12032-014-0859-x |
| Pubmed ID | |
| Authors |
Qing Liu, Hailin Tang, Xiaoping Liu, Yiwei Liao, Haoyu Li, Zijin Zhao, Xianrui Yuan, Weixi Jiang |
| Abstract |
miR-200b is a tumor suppressor in multiple tumors including gastric cancer, breast cancer, ovarian cancer and glioma. In this study, we detected the expression of miR-200b and analyzed its correlation with clinicopathological parameters in glioma tissues. miR-200b was downregulated in glioma tissues. And its downexpression was correlated with poor prognosis in gliomas. Members of RAB family, RAB21, RAB23, RAB18 and RAB3B were predicted to be novel targets of miR-200b. The direct suppression of RAB21, RAB23, RAB18 and RAB3B expressions by miR-200b was revealed by luciferase reporter assay, quantitative RT-PCR analysis and Western blot. Furthermore, the overall survival of patients with different expression of RABs was analyzed. The expression of RAB21, RAB23, RAB18 and RAB3B was related to the prognosis and histopathology of glioma. The patients who had the upregulation of all the four RABs had the worst outcome; those who had the downregulation of all RABs had the best outcome (p<0.001). miR-200b was a potential biomarker for glioma prognosis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 28% |
| Student > Master | 6 | 14% |
| Researcher | 6 | 14% |
| Student > Bachelor | 6 | 14% |
| Student > Doctoral Student | 4 | 9% |
| Other | 3 | 7% |
| Unknown | 6 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 23% |
| Biochemistry, Genetics and Molecular Biology | 9 | 21% |
| Medicine and Dentistry | 9 | 21% |
| Neuroscience | 3 | 7% |
| Computer Science | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 7 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2014.
All research outputs
#20,238,443
of 22,765,347 outputs
Outputs from Medical Oncology
#955
of 1,286 outputs
Outputs of similar age
#266,158
of 307,518 outputs
Outputs of similar age from Medical Oncology
#20
of 28 outputs
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