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Conservation of human alternative splice events in mouse

Overview of attention for article published in Nucleic Acids Research, May 2003
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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1 X user
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2 patents

Citations

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106 Dimensions

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69 Mendeley
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2 CiteULike
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Title
Conservation of human alternative splice events in mouse
Published in
Nucleic Acids Research, May 2003
DOI 10.1093/nar/gkg355
Pubmed ID
Authors

T. A. Thanaraj, Francis Clark, Juha Muilu

Abstract

Human and mouse genomes share similar long-range sequence organization, and have most of their genes being homologous. As alternative splicing is a frequent and important aspect of gene regulation, it is of interest to assess the level of conservation of alternative splicing. We examined mouse transcript data sets (EST and mRNA) for the presence of transcripts that both make spliced-alignment with the draft mouse genome sequence and demonstrate conservation of human transcript-confirmed alternative and constitutive splice junctions. This revealed 15% of alternative and 67% of constitutive splice junctions as conserved; however, these numbers are patently dependent on the extent of transcript coverage. Transcript coverage of conserved splice patterns is found to correlate well between human and mouse. A model, which extrapolates from observed levels of conservation at increasing levels of transcript support, estimates overall conservation of 61% of alternative and 74% of constitutive splice junctions, albeit with broad confidence intervals. Observed numbers of conserved alternative splicing events agreed with those expected on the basis of the model. Thus, it is apparent that many, and probably most, alternative splicing events are conserved between human and mouse. This, combined with the preservation of alternative frame stop codons in conserved frame breaking events, indicates a high level of commonality in patterns of gene expression between these two species.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Germany 1 1%
Australia 1 1%
France 1 1%
Mexico 1 1%
United Kingdom 1 1%
Unknown 62 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 35%
Researcher 20 29%
Student > Master 6 9%
Professor > Associate Professor 5 7%
Student > Doctoral Student 3 4%
Other 5 7%
Unknown 6 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 43 62%
Biochemistry, Genetics and Molecular Biology 9 13%
Computer Science 6 9%
Medicine and Dentistry 2 3%
Chemistry 1 1%
Other 1 1%
Unknown 7 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2020.
All research outputs
#7,960,512
of 25,374,647 outputs
Outputs from Nucleic Acids Research
#12,851
of 27,550 outputs
Outputs of similar age
#17,917
of 54,577 outputs
Outputs of similar age from Nucleic Acids Research
#47
of 98 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 27,550 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 54,577 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.