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DNA Ligase-Based Strategy for Quantifying Heterogeneous DNA Methylation without Sequencing

Overview of attention for article published in Clinical Chemistry, January 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

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3 X users
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2 patents

Citations

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23 Dimensions

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19 Mendeley
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Title
DNA Ligase-Based Strategy for Quantifying Heterogeneous DNA Methylation without Sequencing
Published in
Clinical Chemistry, January 2015
DOI 10.1373/clinchem.2014.227546
Pubmed ID
Authors

Eugene J H Wee, Sakandar Rauf, Muhammad J A Shiddiky, Alexander Dobrovic, Matt Trau

Abstract

DNA methylation is a potential source of disease biomarkers. Typically, methylation levels are measured at individual cytosine/guanine (CpG) sites or over a short region of interest. However, regions of interest often show heterogeneous methylation comprising multiple patterns of methylation (epialleles) on individual DNA strands. Heterogeneous methylation is largely ignored because digital methods are required to deconvolute these usually complex patterns of epialleles. Currently, only single-molecule approaches, such as next generation sequencing (NGS), can provide detailed epiallele information. Because NGS is not yet feasible for routine practice, we developed a single-molecule-like approach, named for epiallele quantification (EpiQ).

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 21%
Researcher 3 16%
Student > Bachelor 2 11%
Other 2 11%
Student > Master 2 11%
Other 1 5%
Unknown 5 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 26%
Biochemistry, Genetics and Molecular Biology 4 21%
Chemistry 2 11%
Medicine and Dentistry 1 5%
Environmental Science 1 5%
Other 0 0%
Unknown 6 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2019.
All research outputs
#6,780,483
of 22,765,347 outputs
Outputs from Clinical Chemistry
#2,420
of 7,372 outputs
Outputs of similar age
#92,789
of 352,895 outputs
Outputs of similar age from Clinical Chemistry
#27
of 68 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,372 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,895 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.