| Title |
Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism
|
|---|---|
| Published in |
Current Environmental Health Reports, October 2017
|
| DOI | 10.1007/s40572-017-0170-z |
| Pubmed ID | |
| Authors |
Carolyn McCabe, Olivia S. Anderson, Luke Montrose, Kari Neier, Dana C. Dolinoy |
| Abstract |
The genetic material of every organism exists within the context of regulatory networks that govern gene expression-collectively called the epigenome. Animal models and human birth cohort studies have revealed key developmental periods that are important for epigenetic programming and vulnerable to environmental insults. Thus, epigenetics represent a potential mechanism through which sexually dimorphic effects of early-life exposures such as endocrine-disrupting chemicals (EDCs) manifest. Several animal studies, and to a lesser extent human studies, have evaluated life-course sexually dimorphic health effects following developmental toxicant exposures; many fewer studies, however, have evaluated epigenetics as a mechanism mediating developmental exposures and later outcomes. To evaluate epigenetic reprogramming as a mechanistic link of sexually dimorphic early-life EDCs exposures, the following criteria should be met: (1) well-characterized exposure paradigm that includes relevant windows for developmental epigenetic reprogramming; (2) evaluation of sex-specific exposure-related epigenetic change; and (3) observation of a sexually dimorphic phenotype in either childhood, adolescence, or adulthood. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Germany | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 18% |
| Student > Bachelor | 9 | 15% |
| Researcher | 9 | 15% |
| Student > Master | 8 | 13% |
| Student > Doctoral Student | 7 | 11% |
| Other | 8 | 13% |
| Unknown | 9 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 20% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Agricultural and Biological Sciences | 9 | 15% |
| Environmental Science | 4 | 7% |
| Neuroscience | 4 | 7% |
| Other | 7 | 11% |
| Unknown | 16 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2023.
All research outputs
#13,957,469
of 24,450,293 outputs
Outputs from Current Environmental Health Reports
#240
of 341 outputs
Outputs of similar age
#156,282
of 327,374 outputs
Outputs of similar age from Current Environmental Health Reports
#9
of 12 outputs
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