Title |
Pre-pulse inhibition and antisaccade performance indicate impaired attention modulation of cognitive inhibition in 22q11.2 deletion syndrome (22q11DS)
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Published in |
Journal of Neurodevelopmental Disorders, September 2014
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DOI | 10.1186/1866-1955-6-38 |
Pubmed ID | |
Authors |
Kathryn Louise McCabe, Rebbekah Josephine Atkinson, Gavin Cooper, Jessica Lauren Melville, Jill Harris, Ulrich Schall, Carmel Maree Loughland, Renate Thienel, Linda Elisabet Campbell |
Abstract |
22q11.2 deletion syndrome (22q11DS) is associated with a number of physical anomalies and neuropsychological deficits including impairments in executive and sensorimotor function. It is estimated that 25% of children with 22q11DS will develop schizophrenia and other psychotic disorders later in life. Evidence of genetic transmission of information processing deficits in schizophrenia suggests performance in 22q11DS individuals will enhance understanding of the neurobiological and genetic substrates associated with information processing. In this report, we examine information processing in 22q11DS using measures of startle eyeblink modification and antisaccade inhibition to explore similarities with schizophrenia and associations with neurocognitive performance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 24% |
Student > Ph. D. Student | 12 | 22% |
Student > Doctoral Student | 9 | 17% |
Student > Postgraduate | 4 | 7% |
Student > Bachelor | 3 | 6% |
Other | 6 | 11% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 15 | 28% |
Medicine and Dentistry | 10 | 19% |
Neuroscience | 7 | 13% |
Agricultural and Biological Sciences | 6 | 11% |
Nursing and Health Professions | 2 | 4% |
Other | 6 | 11% |
Unknown | 8 | 15% |