| Title |
Neuromodulation Integrating rTMS and Neurofeedback for the Treatment of Autism Spectrum Disorder: An Exploratory Study
|
|---|---|
| Published in |
Applied Psychophysiology and Biofeedback, September 2014
|
| DOI | 10.1007/s10484-014-9264-7 |
| Pubmed ID | |
| Authors |
Estate M. Sokhadze, Ayman S. El-Baz, Allan Tasman, Lonnie L. Sears, Yao Wang, Eva V. Lamina, Manuel F. Casanova |
| Abstract |
Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by deficits in social interaction, language, stereotyped behaviors, and restricted range of interests. In previous studies low frequency repetitive transcranial magnetic stimulation (rTMS) has been used, with positive behavioral and electrophysiological results, for the experimental treatment in ASD. In this study we combined prefrontal rTMS sessions with electroencephalographic (EEG) neurofeedback (NFB) to prolong and reinforce TMS-induced EEG changes. The pilot trial recruited 42 children with ASD (~14.5 years). Outcome measures included behavioral evaluations and reaction time test with event-related potential (ERP) recording. For the main goal of this exploratory study we used rTMS-neurofeedback combination (TMS-NFB, N = 20) and waitlist (WTL, N = 22) groups to examine effects of 18 sessions of integrated rTMS-NFB treatment or wait period) on behavioral responses, stimulus and response-locked ERPs, and other functional and clinical outcomes. The underlying hypothesis was that combined TMS-NFB will improve executive functions in autistic patients as compared to the WTL group. Behavioral and ERP outcomes were collected in pre- and post-treatment tests in both groups. Results of the study supported our hypothesis by demonstration of positive effects of combined TMS-NFB neurotherapy in active treatment group as compared to control WTL group, as the TMS-NFB group showed significant improvements in behavioral and functional outcomes as compared to the WTL group. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Japan | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 225 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 38 | 17% |
| Student > Ph. D. Student | 27 | 12% |
| Researcher | 26 | 11% |
| Student > Bachelor | 24 | 11% |
| Student > Doctoral Student | 15 | 7% |
| Other | 48 | 21% |
| Unknown | 50 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 75 | 33% |
| Neuroscience | 25 | 11% |
| Medicine and Dentistry | 24 | 11% |
| Social Sciences | 9 | 4% |
| Engineering | 9 | 4% |
| Other | 20 | 9% |
| Unknown | 66 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2023.
All research outputs
#7,668,535
of 24,633,436 outputs
Outputs from Applied Psychophysiology and Biofeedback
#172
of 449 outputs
Outputs of similar age
#77,108
of 257,975 outputs
Outputs of similar age from Applied Psychophysiology and Biofeedback
#7
of 12 outputs
Altmetric has tracked 24,633,436 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 449 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has gotten more attention than average, scoring higher than 61% of its peers.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.