| Chapter title |
Plant-Based Oral Vaccines: Results of Human Trials
|
|---|---|
| Chapter number | 6 |
| Book title |
Plant-produced Microbial Vaccines
|
| Published in |
Current topics in microbiology and immunology, January 2010
|
| DOI | 10.1007/978-3-540-70868-1_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-54-070857-5, 978-3-54-070868-1
|
| Authors |
C. O. Tacket, Tacket, C. O. |
| Abstract |
Vaccines consisting of transgenic plant-derived antigens offer a new strategy for development of safe, inexpensive vaccines. The vaccine antigens can be eaten with the edible part of the plant or purified from plant material. In phase 1 clinical studies of prototype potato- and corn-based vaccines, these vaccines have been safe and immunogenic without the need for a buffer or vehicle other than the plant cell. Transgenic plant technology is attractive for vaccine development because these vaccines are needle-less, stable, and easy to administer. This chapter examines some early human studies of oral transgenic plant-derived vaccines against enterotoxigenic Escherichia coli infection, norovirus, and hepatitis B. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Pakistan | 1 | 2% |
| Australia | 1 | 2% |
| Slovakia | 1 | 2% |
| Mexico | 1 | 2% |
| United States | 1 | 2% |
| Serbia | 1 | 2% |
| Unknown | 47 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 26% |
| Student > Master | 10 | 19% |
| Researcher | 5 | 9% |
| Student > Bachelor | 4 | 8% |
| Other | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 40% |
| Biochemistry, Genetics and Molecular Biology | 7 | 13% |
| Medicine and Dentistry | 3 | 6% |
| Immunology and Microbiology | 2 | 4% |
| Social Sciences | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 16 | 30% |