Title |
Comparison of Different Ion Mobility Setups Using Poly (Ethylene Oxide) PEO Polymers: Drift Tube, TIMS, and T-Wave
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Published in |
Journal of the American Society for Mass Spectrometry, October 2017
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DOI | 10.1007/s13361-017-1822-9 |
Pubmed ID | |
Authors |
Jean R. N. Haler, Philippe Massonnet, Fabien Chirot, Christopher Kune, Clothilde Comby-Zerbino, Jan Jordens, Maarten Honing, Ynze Mengerink, Johann Far, Philippe Dugourd, Edwin De Pauw |
Abstract |
Over the years, polymer analyses using ion mobility-mass spectrometry (IM-MS) measurements have been performed on different ion mobility spectrometry (IMS) setups. In order to be able to compare literature data taken on different IM(-MS) instruments, ion heating and ion temperature evaluations have already been explored. Nevertheless, extrapolations to other analytes are difficult and thus straightforward same-sample instrument comparisons seem to be the only reliable way to make sure that the different IM(-MS) setups do not greatly change the gas-phase behavior. We used a large range of degrees of polymerization (DP) of poly(ethylene oxide) PEO homopolymers to measure IMS drift times on three different IM-MS setups: a homemade drift tube (DT), a trapped (TIMS), and a traveling wave (T-Wave) IMS setup. The drift time evolutions were followed for increasing polymer DPs (masses) and charge states, and they are found to be comparable and reproducible on the three instruments. ᅟ. |
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