| Title |
The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis
|
|---|---|
| Published in |
Archivum Immunologiae et Therapiae Experimentalis, October 2014
|
| DOI | 10.1007/s00005-014-0310-1 |
| Pubmed ID | |
| Authors |
Agata Kowalczyk, Paulina Kleniewska, Michal Kolodziejczyk, Beata Skibska, Anna Goraca |
| Abstract |
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-κB and expression of proinflammatory cytokines including TNF-α, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases. This review summarises the current knowledge regarding endothelin receptor antagonists and the role of ET-1 in sepsis and inflammation. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 346 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Turkey | 1 | <1% |
| Colombia | 1 | <1% |
| Unknown | 343 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 64 | 18% |
| Student > Master | 41 | 12% |
| Student > Ph. D. Student | 37 | 11% |
| Student > Doctoral Student | 21 | 6% |
| Researcher | 20 | 6% |
| Other | 58 | 17% |
| Unknown | 105 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 74 | 21% |
| Biochemistry, Genetics and Molecular Biology | 49 | 14% |
| Agricultural and Biological Sciences | 30 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 27 | 8% |
| Engineering | 9 | 3% |
| Other | 49 | 14% |
| Unknown | 108 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2024.
All research outputs
#3,665,243
of 25,605,018 outputs
Outputs from Archivum Immunologiae et Therapiae Experimentalis
#45
of 409 outputs
Outputs of similar age
#39,931
of 268,062 outputs
Outputs of similar age from Archivum Immunologiae et Therapiae Experimentalis
#1
of 9 outputs
Altmetric has tracked 25,605,018 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 409 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,062 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them