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Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface

Overview of attention for article published in American Journal of Physiology: Gastrointestinal & Liver Physiology, October 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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1 blog
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28 X users
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2 Facebook pages

Citations

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119 Mendeley
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Title
Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface
Published in
American Journal of Physiology: Gastrointestinal & Liver Physiology, October 2017
DOI 10.1152/ajpgi.00249.2017
Pubmed ID
Authors

John L Wallace, Jean-Paul Motta, Andre G Buret

Abstract

A diverse range of effects of the intestinal microbiota on mucosal defence and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defence and repair. Hydrogen sulfide is produced gastrointestinal tract tissues and by bacteria residing within the gut, and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide. H2S donors can modify the gut microbiota and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H2S. When administered together with nonsteroidal anti-inflammatory drugs, H2S can prevent some of the dysbiosis those drugs induce, possibly contributing to the observed prevention of gastrointestinal damage. Exogenous H2S can also markedly reduce the severity of experimental colitis and plays important roles in modulating epithelial cell-mucus-bacterial interactions in the intestine, contributing to its ability to promote resolution of inflammation and repair of tissue injury. In this paper we review recent studies examining the roles of H2S in mucosal defence, the possibility that H2S can damage the GI epithelium, effects of H2S on the gut microbiota and on mucus and biofilm interactions in the context of intestinal inflammation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 119 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 19%
Researcher 18 15%
Student > Bachelor 12 10%
Student > Postgraduate 9 8%
Student > Master 9 8%
Other 21 18%
Unknown 27 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 14%
Agricultural and Biological Sciences 16 13%
Medicine and Dentistry 12 10%
Immunology and Microbiology 10 8%
Chemistry 5 4%
Other 31 26%
Unknown 28 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2021.
All research outputs
#1,548,325
of 25,564,614 outputs
Outputs from American Journal of Physiology: Gastrointestinal & Liver Physiology
#78
of 2,224 outputs
Outputs of similar age
#30,658
of 334,611 outputs
Outputs of similar age from American Journal of Physiology: Gastrointestinal & Liver Physiology
#3
of 35 outputs
Altmetric has tracked 25,564,614 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,224 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,611 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.