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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Fracture Healing via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Early Endochondral Ossification
|
|---|---|
| Published in |
American Journal of Pathology, October 2014
|
| DOI | 10.1016/j.ajpath.2014.08.017 |
| Pubmed ID | |
| Authors |
Liza J. Raggatt, Martin E. Wullschleger, Kylie A. Alexander, Andy C.K. Wu, Susan M. Millard, Simranpreet Kaur, Michelle L. Maugham, Laura S. Gregory, Roland Steck, Allison R. Pettit |
| Abstract |
The distribution, phenotype, and requirement of macrophages for fracture-associated inflammation and/or early anabolic progression during endochondral callus formation were investigated. A murine femoral fracture model [internally fixed using a flexible plate (MouseFix)] was used to facilitate reproducible fracture reduction. IHC demonstrated that inflammatory macrophages (F4/80(+)Mac-2(+)) were localized with initiating chondrification centers and persisted within granulation tissue at the expanding soft callus front. They were also associated with key events during soft-to-hard callus transition. Resident macrophages (F4/80(+)Mac-2(neg)), including osteal macrophages, predominated in the maturing hard callus. Macrophage Fas-induced apoptosis transgenic mice were used to induce macrophage depletion in vivo in the femoral fracture model. Callus formation was completely abolished when macrophage depletion was initiated at the time of surgery and was significantly reduced when depletion was delayed to coincide with initiation of early anabolic phase. Treatment initiating 5 days after fracture with the pro-macrophage cytokine colony stimulating factor-1 significantly enhanced soft callus formation. The data support that inflammatory macrophages were required for initiation of fracture repair, whereas both inflammatory and resident macrophages promoted anabolic mechanisms during endochondral callus formation. Overall, macrophages make substantive and prolonged contributions to fracture healing and can be targeted as a therapeutic approach for enhancing repair mechanisms. Thus, macrophages represent a viable target for the development of pro-anabolic fracture treatments with a potentially broad therapeutic window. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 2 | 50% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Australia | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 205 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 22% |
| Student > Master | 26 | 13% |
| Researcher | 23 | 11% |
| Student > Bachelor | 21 | 10% |
| Student > Doctoral Student | 13 | 6% |
| Other | 26 | 13% |
| Unknown | 53 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 21% |
| Biochemistry, Genetics and Molecular Biology | 25 | 12% |
| Agricultural and Biological Sciences | 24 | 12% |
| Engineering | 10 | 5% |
| Materials Science | 9 | 4% |
| Other | 25 | 12% |
| Unknown | 72 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#6,559,003
of 25,728,855 outputs
Outputs from American Journal of Pathology
#1,735
of 5,943 outputs
Outputs of similar age
#64,463
of 267,170 outputs
Outputs of similar age from American Journal of Pathology
#13
of 58 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 5,943 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,170 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.