| Title |
Immunological aspects of rabies: a literature review
|
|---|---|
| Published in |
Archives of Virology, July 2017
|
| DOI | 10.1007/s00705-017-3484-0 |
| Pubmed ID | |
| Authors |
Iana Suly Santos Katz, Fernanda Guedes, Elaine Raniero Fernandes, Sandriana dos Ramos Silva |
| Abstract |
Rabies is a lethal disease caused by the neurotropic virus rabies virus (RABV), and it remains an important public health problem globally. It is known that the host immune response is important for control of viral infection and promoting viral clearance. In this context, it is well documented that, in addition to RABV neutralizing antibody, interferons and cell-mediated immunity also have an important role in preventing the establishment of disease. On the other hand, RABV suppresses host immunity through different mechanisms, for example, direct inhibition of host gene expression, sequestration of pathogen-associated molecular patterns, or modification of cytokine signalling pathways, which hinder the protective host immune responses to RABV infection. Here, we review the immunological aspects of rabies, highlighting innate and adaptive immunity, as well as the host evasion immune mechanisms used by the virus. Finally, we briefly discuss how this knowledge can direct new research and be harnessed for future therapeutic strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 125 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 16% |
| Student > Bachelor | 15 | 12% |
| Researcher | 12 | 10% |
| Student > Ph. D. Student | 9 | 7% |
| Student > Doctoral Student | 8 | 6% |
| Other | 16 | 13% |
| Unknown | 45 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 17% |
| Immunology and Microbiology | 11 | 9% |
| Biochemistry, Genetics and Molecular Biology | 10 | 8% |
| Veterinary Science and Veterinary Medicine | 9 | 7% |
| Medicine and Dentistry | 8 | 6% |
| Other | 18 | 14% |
| Unknown | 48 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2017.
All research outputs
#18,573,839
of 23,005,189 outputs
Outputs from Archives of Virology
#3,055
of 4,206 outputs
Outputs of similar age
#241,326
of 315,207 outputs
Outputs of similar age from Archives of Virology
#44
of 82 outputs
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