| Title |
Correlation between 18F-fluoromisonidazole PET and expression of HIF-1α and VEGF in newly diagnosed and recurrent malignant gliomas
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, April 2014
|
| DOI | 10.1007/s00259-014-2776-9 |
| Pubmed ID | |
| Authors |
Nobuyuki Kawai, Wei Lin, Wei-Dong Cao, Daisuke Ogawa, Keisuke Miyake, Reiji Haba, Yukito Maeda, Yuka Yamamoto, Yoshihiro Nishiyama, Takashi Tamiya |
| Abstract |
Hypoxia and its consequences at the molecular level promote tumour progression and affect patient prognosis. One of the main early cellular events evoked by hypoxia is induction of hypoxia-inducible factor 1 (HIF-1) and subsequent upregulation of vascular endothelial growth factor (VEGF). In this study we sought to determine whether hypoxia detected by (18)F-fluoromisonidazole (FMISO) PET accurately reflects the expression of HIF-1α and VEGF in the tumour and can be used as a biomarker of antiangiogenic treatment and as a prognostic factor in newly diagnosed and recurrent malignant gliomas. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 44 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 18% |
| Student > Master | 7 | 16% |
| Student > Ph. D. Student | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Other | 8 | 18% |
| Unknown | 10 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 42% |
| Neuroscience | 5 | 11% |
| Agricultural and Biological Sciences | 3 | 7% |
| Mathematics | 2 | 4% |
| Chemistry | 2 | 4% |
| Other | 3 | 7% |
| Unknown | 11 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2014.
All research outputs
#19,214,418
of 23,806,312 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#2,305
of 3,083 outputs
Outputs of similar age
#166,325
of 228,543 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#24
of 41 outputs
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