| Title |
Histone chaperone CAF-1: essential roles in multi-cellular organism development
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2014
|
| DOI | 10.1007/s00018-014-1748-3 |
| Pubmed ID | |
| Authors |
Zhongsheng Yu, Jiyong Liu, Wu-Min Deng, Renjie Jiao |
| Abstract |
More and more studies have shown chromatin remodelers and histone modifiers play essential roles in regulating developmental patterns by organizing specific chromosomal architecture to establish programmed transcriptional profiles, with implications that histone chaperones execute a coordinating role in these processes. Chromatin assembly factor-1 (CAF-1), an evolutionarily conserved three-subunit protein complex, was identified as a histone chaperone coupled with DNA replication and repair in cultured mammalian cells and yeasts. Interestingly, recent findings indicate CAF-1 may have important regulatory roles during development by interacting with specific transcription factors and epigenetic regulators. In this review, we focus on the essential roles of CAF-1 in regulating heterochromatin organization, asymmetric cell division, and specific signal transduction through epigenetic modulations of the chromatin. In the end, we aim at providing a current image of facets of CAF-1 as a histone chaperone to orchestrate cell proliferation and differentiation during multi-cellular organism development. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Mexico | 1 | 1% |
| United States | 1 | 1% |
| France | 1 | 1% |
| Unknown | 64 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 29% |
| Student > Ph. D. Student | 17 | 25% |
| Student > Doctoral Student | 5 | 7% |
| Professor > Associate Professor | 5 | 7% |
| Student > Postgraduate | 4 | 6% |
| Other | 8 | 12% |
| Unknown | 9 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 40% |
| Agricultural and Biological Sciences | 23 | 34% |
| Medicine and Dentistry | 4 | 6% |
| Psychology | 1 | 1% |
| Computer Science | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 10 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2015.
All research outputs
#7,145,757
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,515
of 4,151 outputs
Outputs of similar age
#74,395
of 256,843 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#12
of 53 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,843 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.