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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease for Pleural Infection. An Effective and Safe Alternative to Surgery
|
|---|---|
| Published in |
Annals of the American Thoracic Society, November 2014
|
| DOI | 10.1513/annalsats.201407-329oc |
| Pubmed ID | |
| Authors |
Francesco Piccolo, Nicholas Pitman, Rahul Bhatnagar, Natalia Popowicz, Nicola A. Smith, Ben Brockway, Robert Nickels, Andrew J. Burke, Conroy A. Wong, Ruth McCartney, Brian Choo-Kang, Kevin G. Blyth, Nick A. Maskell, Y. C. Gary Lee |
| Abstract |
Rationale: Intrapleural tPA/DNase therapy for pleural infection given at the time of diagnosis has been shown to significantly improve radiological outcomes. Published cases are limited to a single randomized control trial and few case reports only. Objective: Multinational observation series to evaluate the pragmatic "real-life" application of tPA/DNase treatment for pleural infection in a large cohort of unselected patients. Methods: All patients from eight centers who received intrapleural tPA/DNase for pleural infection between January 2010 and September 2013 were included. Measured outcomes included treatment success at 30 days, volume of pleural fluid drained, improvement in radiographic pleural opacity and inflammatory markers, need for surgery and adverse events. Measurement and Main Results: Of 107 patients treated, the majority (92.3%) were successfully managed without necessitating surgical intervention. No patients died from pleural infection. Most (84%) patients received tPA/DNase more than 24 hours after failing to respond to initial conservative management with antibiotics and thoracostomy. tPA/DNase increased fluid drained from 250mL(median, IQR 100-654) in the preceding 24h to 2475mL(1800-3585) in the 72h following commencement of intrapleural therapy (p<0.05). A corresponding clearance of pleural opacity on chest radiographs from 35% (median, IQR 25-31) to 14% (7-28) of the hemithorax (p<0.001), and significant reduction in C-reactive protein (p<0.05) were observed. Pain necessitating escalation of analgesia occurred in 19.6% and non-fatal bleeding in 1.8% of patients. Conclusion: This largest series of intrapleural tPA/DNase therapy provides important evidence that the treatment is effective and safe especially as a 'rescue therapy' in patients who failed to initially respond to antibiotics and thoracostomy drainage. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 33% |
| Kuwait | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 21% |
| Other | 9 | 13% |
| Student > Bachelor | 9 | 13% |
| Student > Postgraduate | 7 | 10% |
| Student > Ph. D. Student | 4 | 6% |
| Other | 8 | 12% |
| Unknown | 17 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 53% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Agricultural and Biological Sciences | 2 | 3% |
| Social Sciences | 2 | 3% |
| Nursing and Health Professions | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 22 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2023.
All research outputs
#3,895,991
of 23,342,092 outputs
Outputs from Annals of the American Thoracic Society
#1,004
of 2,996 outputs
Outputs of similar age
#45,091
of 262,029 outputs
Outputs of similar age from Annals of the American Thoracic Society
#16
of 84 outputs
Altmetric has tracked 23,342,092 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,996 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.6. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,029 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.