| Title |
Gene Therapy for Autoimmune Disease
|
|---|---|
| Published in |
Clinical Reviews in Allergy & Immunology, October 2014
|
| DOI | 10.1007/s12016-014-8451-x |
| Pubmed ID | |
| Authors |
Shang-An Shu, Jinjun Wang, Mi-Hua Tao, Patrick S. C. Leung |
| Abstract |
Advances in understanding the immunological and molecular basis of autoimmune diseases have made gene therapy a promising approach to treat the affected patients. Gene therapy for autoimmune diseases aims to regulate the levels of proinflammatory cytokines or molecules and the infiltration of lymphocytes to the effected sites through successful delivery and expression of therapeutic genes in appropriate cells. The ultimate goal of gene therapy is to restore and maintain the immune tolerance to the relevant autoantigens and improve clinical outcomes for patients. Here, we summarize the recent progress in identifying genes responsible for autoimmune diseases and present examples where gene therapy has been applied as treatments or prevention in autoimmune diseases both in animal models and the clinical trials. Discussion on the advantages and pitfalls of gene therapy strategies employed is provided. The intent of this review is to inspire further studies toward the development of new strategies for successful treatment of autoimmune diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Spain | 1 | <1% |
| Unknown | 116 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 36 | 30% |
| Student > Ph. D. Student | 13 | 11% |
| Researcher | 10 | 8% |
| Other | 8 | 7% |
| Student > Postgraduate | 8 | 7% |
| Other | 18 | 15% |
| Unknown | 26 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 21 | 18% |
| Medicine and Dentistry | 19 | 16% |
| Agricultural and Biological Sciences | 14 | 12% |
| Immunology and Microbiology | 9 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Other | 18 | 15% |
| Unknown | 32 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2023.
All research outputs
#1,758,246
of 24,143,470 outputs
Outputs from Clinical Reviews in Allergy & Immunology
#53
of 691 outputs
Outputs of similar age
#19,971
of 258,474 outputs
Outputs of similar age from Clinical Reviews in Allergy & Immunology
#2
of 15 outputs
Altmetric has tracked 24,143,470 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 691 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.