You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
|
|---|---|
| Published in |
Cell, October 2014
|
| DOI | 10.1016/j.cell.2014.09.010 |
| Pubmed ID | |
| Authors |
Hai-Bin Ruan, Marcelo O. Dietrich, Zhong-Wu Liu, Marcelo R. Zimmer, Min-Dian Li, Jay Prakash Singh, Kaisi Zhang, Ruonan Yin, Jing Wu, Tamas L. Horvath, Xiaoyong Yang |
| Abstract |
Induction of beige cells causes the browning of white fat and improves energy metabolism. However, the central mechanism that controls adipose tissue browning and its physiological relevance are largely unknown. Here, we demonstrate that fasting and chemical-genetic activation of orexigenic AgRP neurons in the hypothalamus suppress the browning of white fat. O-linked β-N-acetylglucosamine (O-GlcNAc) modification of cytoplasmic and nuclear proteins regulates fundamental cellular processes. The levels of O-GlcNAc transferase (OGT) and O-GlcNAc modification are enriched in AgRP neurons and are elevated by fasting. Genetic ablation of OGT in AgRP neurons inhibits neuronal excitability through the voltage-dependent potassium channel, promotes white adipose tissue browning, and protects mice against diet-induced obesity and insulin resistance. These data reveal adipose tissue browning as a highly dynamic physiological process under central control, in which O-GlcNAc signaling in AgRP neurons is essential for suppressing thermogenesis to conserve energy in response to fasting. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 25% |
| Spain | 5 | 21% |
| United Kingdom | 2 | 8% |
| Netherlands | 1 | 4% |
| Peru | 1 | 4% |
| Unknown | 9 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 75% |
| Scientists | 4 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 212 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| China | 1 | <1% |
| Italy | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 208 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 24% |
| Researcher | 41 | 19% |
| Student > Master | 15 | 7% |
| Student > Doctoral Student | 13 | 6% |
| Student > Bachelor | 12 | 6% |
| Other | 41 | 19% |
| Unknown | 39 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 65 | 31% |
| Biochemistry, Genetics and Molecular Biology | 42 | 20% |
| Medicine and Dentistry | 20 | 9% |
| Neuroscience | 18 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 20 | 9% |
| Unknown | 43 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 121. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2015.
All research outputs
#352,364
of 26,017,215 outputs
Outputs from Cell
#1,903
of 17,318 outputs
Outputs of similar age
#3,345
of 269,687 outputs
Outputs of similar age from Cell
#29
of 148 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,318 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.5. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,687 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 148 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.