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Borrelia burgdorferi

Overview of attention for book
Cover of 'Borrelia burgdorferi'

Table of Contents

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    Book Overview
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    Chapter 1 Genotyping Strains of Lyme Disease Agents Directly From Ticks, Blood, or Tissue
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    Chapter 2 Species Identification and Phylogenetic Analysis of Borrelia burgdorferi Sensu Lato Using Molecular Biological Methods
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    Chapter 3 Generation of Mammalian Host-Adapted Borrelia burgdorferi by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats
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    Chapter 4 Co-immunoprecipitation for Identifying Protein-Protein Interactions in Borrelia burgdorferi
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    Chapter 5 Characterization of Borrelia burgdorferi Binding to Mammalian Cells and Extracellular Matrix
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    Chapter 6 Analysis of Lipids and Lipid Rafts in Borrelia
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    Chapter 7 Trace Element Analysis of Borrelia burgdorferi by Inductively Coupled Plasma-Sector Field Mass Spectrometry
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    Chapter 8 Identification and Characterization of Borrelia burgdorferi Complement-Binding Proteins
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    Chapter 9 Artificial Infection of Ticks with Borrelia burgdorferi Using a Microinjection Method and Their Detection In Vivo Using Quantitative PCR Targeting flaB RNA
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    Chapter 10 Borrelia burgdorferi Microarray Analysis
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    Chapter 11 Borrelia burgdorferi Transcriptome Analysis by RNA-Sequencing
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    Chapter 12 Selection of Borrelia burgdorferi Promoter Sequences Active During Mammalian Infection Using In Vivo Expression Technology
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    Chapter 13 Analysis of DNA and RNA Binding Properties of Borrelia burgdorferi Regulatory Proteins
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    Chapter 14 Identification of Acetylated Proteins in Borrelia burgdorferi
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    Chapter 15 Genetic Transformation and Complementation
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    Chapter 16 Genome-Wide Mutagenesis in Borrelia burgdorferi
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    Chapter 17 Generation of Conditional Mutants in Borrelia burgdorferi
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    Chapter 18 Detection of Bioluminescent Borrelia burgdorferi from In Vitro Cultivation and During Murine Infection
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    Chapter 19 Analysis of Borrelia burgdorferi Proteome and Protein–Protein Interactions
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    Chapter 20 Two Photon Intravital Microscopy of Lyme Borrelia in Mice
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    Chapter 21 Investigating Human Dendritic Cell Immune Responses to Borrelia burgdorferi
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    Chapter 22 Phagocytosis Assays for Borrelia burgdorferi
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    Chapter 23 Measuring Borrelia burgdorferi Motility and Chemotaxis
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    Chapter 24 In Vitro Models of Cutaneous Inflammation
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    Chapter 25 Magnetic Isolation of Phagosomes Containing Toll-Like Receptor Ligands
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    Chapter 26 Xenodiagnosis Using Ixodes scapularis Larval Ticks in Humans
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    Chapter 27 Recombinant E. coli Dualistic Role as an Antigen-adjuvant Delivery Vehicle for Oral Immunization
Attention for Chapter 3: Generation of Mammalian Host-Adapted Borrelia burgdorferi by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats
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Chapter title
Generation of Mammalian Host-Adapted Borrelia burgdorferi by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats
Chapter number 3
Book title
Borrelia burgdorferi
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7383-5_3
Pubmed ID
Book ISBNs
978-1-4939-7382-8, 978-1-4939-7383-5
Authors

Melissa J. Caimano

Abstract

The transmission, survival, and virulence of Borrelia burgdorferi depend upon the spirochete's ability to modulate its transcriptome as it cycles between its arthropod vector and reservoir host. This complex adaptive process is collectively referred to as "host-adaptation." The paucibacillary nature of borrelial infections precludes the detailed analysis of host adaptation within infected mammalian tissues. To circumvent this limitation, we (J Clin Invest 101:2240-2250, 1998) developed a model system whereby spirochetes are cultivated within dialysis membrane chambers (DMCs) surgically implanted within the peritoneal cavity of a rat. Spirochetes within DMCs are exposed to many, if not all, of the environmental signals and physiological cues required for mammalian host adaptation but are protected from clearance by the host's immune system.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 14%
Student > Ph. D. Student 2 14%
Researcher 2 14%
Other 1 7%
Professor 1 7%
Other 3 21%
Unknown 3 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 21%
Medicine and Dentistry 2 14%
Immunology and Microbiology 2 14%
Nursing and Health Professions 1 7%
Unspecified 1 7%
Other 2 14%
Unknown 3 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2017.
All research outputs
#13,571,666
of 23,006,268 outputs
Outputs from Methods in molecular biology
#3,653
of 13,160 outputs
Outputs of similar age
#219,960
of 442,254 outputs
Outputs of similar age from Methods in molecular biology
#351
of 1,498 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,160 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,254 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,498 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.