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Geometric Control of Cell Life and Death

Overview of attention for article published in Science, May 1997
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

blogs
1 blog
twitter
38 X users
patent
127 patents
peer_reviews
1 peer review site
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
4273 Dimensions

Readers on

mendeley
2321 Mendeley
citeulike
6 CiteULike
connotea
2 Connotea
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Title
Geometric Control of Cell Life and Death
Published in
Science, May 1997
DOI 10.1126/science.276.5317.1425
Pubmed ID
Authors

Christopher S. Chen, Milan Mrksich, Sui Huang, George M. Whitesides, Donald E. Ingber

Abstract

Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension. Cell spreading also was varied while maintaining the total cell-matrix contact area constant by changing the spacing between multiple focal adhesion-sized islands. Cell shape was found to govern whether individual cells grow or die, regardless of the type of matrix protein or antibody to integrin used to mediate adhesion. Local geometric control of cell growth and viability may therefore represent a fundamental mechanism for developmental regulation within the tissue microenvironment.

X Demographics

X Demographics

The data shown below were collected from the profiles of 38 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2,321 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 57 2%
United Kingdom 21 <1%
France 10 <1%
Germany 8 <1%
India 6 <1%
Japan 5 <1%
Switzerland 3 <1%
Australia 3 <1%
Canada 3 <1%
Other 24 1%
Unknown 2181 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 754 32%
Researcher 371 16%
Student > Master 256 11%
Student > Bachelor 215 9%
Professor > Associate Professor 118 5%
Other 375 16%
Unknown 232 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 569 25%
Engineering 527 23%
Biochemistry, Genetics and Molecular Biology 222 10%
Materials Science 157 7%
Chemistry 154 7%
Other 381 16%
Unknown 311 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2024.
All research outputs
#968,925
of 25,391,471 outputs
Outputs from Science
#17,865
of 81,644 outputs
Outputs of similar age
#292
of 29,614 outputs
Outputs of similar age from Science
#14
of 253 outputs
Altmetric has tracked 25,391,471 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 81,644 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.4. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 29,614 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 253 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.