Title |
Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing
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Published in |
Nature Communications, October 2017
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DOI | 10.1038/s41467-017-01194-z |
Pubmed ID | |
Authors |
Sandra Romero-Hidalgo, Adrián Ochoa-Leyva, Alejandro Garcíarrubio, Victor Acuña-Alonzo, Erika Antúnez-Argüelles, Martha Balcazar-Quintero, Rodrigo Barquera-Lozano, Alessandra Carnevale, Fernanda Cornejo-Granados, Juan Carlos Fernández-López, Rodrigo García-Herrera, Humberto García-Ortíz, Ángeles Granados-Silvestre, Julio Granados, Fernando Guerrero-Romero, Enrique Hernández-Lemus, Paola León-Mimila, Gastón Macín-Pérez, Angélica Martínez-Hernández, Marta Menjivar, Enrique Morett, Lorena Orozco, Guadalupe Ortíz-López, Fernando Pérez-Villatoro, Javier Rivera-Morales, Fernando Riveros-McKay, Marisela Villalobos-Comparán, Hugo Villamil-Ramírez, Teresa Villarreal-Molina, Samuel Canizales-Quinteros, Xavier Soberón |
Abstract |
Understanding the genetic structure of Native American populations is important to clarify their diversity, demographic history, and to identify genetic factors relevant for biomedical traits. Here, we show a demographic history reconstruction from 12 Native American whole genomes belonging to six distinct ethnic groups representing the three main described genetic clusters of Mexico (Northern, Southern, and Maya). Effective population size estimates of all Native American groups remained below 2,000 individuals for up to 10,000 years ago. The proportion of missense variants predicted as damaging is higher for undescribed (~ 30%) than for previously reported variants (~ 15%). Several variants previously associated with biological traits are highly frequent in the Native American genomes. These findings suggest that the demographic and adaptive processes that occurred in these groups shaped their genetic architecture and could have implications in biological processes of the Native Americans and Mestizos of today. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 25 | 19% |
Mexico | 23 | 18% |
United Kingdom | 4 | 3% |
Australia | 3 | 2% |
Canada | 3 | 2% |
Sweden | 2 | 2% |
Netherlands | 1 | <1% |
Indonesia | 1 | <1% |
Spain | 1 | <1% |
Other | 7 | 5% |
Unknown | 59 | 46% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 115 | 89% |
Scientists | 13 | 10% |
Practitioners (doctors, other healthcare professionals) | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 146 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 27 | 18% |
Researcher | 22 | 15% |
Student > Master | 22 | 15% |
Student > Ph. D. Student | 20 | 14% |
Professor | 11 | 8% |
Other | 23 | 16% |
Unknown | 21 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 47 | 32% |
Agricultural and Biological Sciences | 23 | 16% |
Medicine and Dentistry | 10 | 7% |
Chemistry | 6 | 4% |
Immunology and Microbiology | 6 | 4% |
Other | 22 | 15% |
Unknown | 32 | 22% |