Title |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic
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Published in |
PLoS Neglected Tropical Diseases, October 2014
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DOI | 10.1371/journal.pntd.0003204 |
Pubmed ID | |
Authors |
Bruno Levecke, Antonio Montresor, Marco Albonico, Shaali M. Ame, Jerzy M. Behnke, Jeffrey M. Bethony, Calvine D. Noumedem, Dirk Engels, Bertrand Guillard, Andrew C. Kotze, Alejandro J. Krolewiecki, James S. McCarthy, Zeleke Mekonnen, Maria V. Periago, Hem Sopheak, Louis-Albert Tchuem-Tchuenté, Tran Thanh Duong, Nguyen Thu Huong, Ahmed Zeynudin, Jozef Vercruysse |
Abstract |
Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugs in preventive chemotherapy (PC) programs for controlling soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura, and hookworm) are still lacking. However, they are urgently needed to ensure detection of reduced efficacies that are predicted to occur due to growing drug pressure. Here, using a standardized methodology, we assessed the FECR rate of a single oral dose of mebendazole (MEB; 500 mg) against STHs in six trials in school children in different locations around the world. Our results are compared with those previously obtained for similarly conducted trials of a single oral dose of albendazole (ALB; 400 mg). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
United Kingdom | 1 | 13% |
Canada | 1 | 13% |
Netherlands | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Scientists | 2 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | <1% |
United Kingdom | 1 | <1% |
Denmark | 1 | <1% |
India | 1 | <1% |
Unknown | 231 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 36 | 15% |
Student > Master | 32 | 14% |
Student > Bachelor | 30 | 13% |
Student > Ph. D. Student | 28 | 12% |
Student > Postgraduate | 12 | 5% |
Other | 45 | 19% |
Unknown | 53 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 53 | 22% |
Agricultural and Biological Sciences | 29 | 12% |
Biochemistry, Genetics and Molecular Biology | 19 | 8% |
Nursing and Health Professions | 14 | 6% |
Immunology and Microbiology | 12 | 5% |
Other | 47 | 20% |
Unknown | 62 | 26% |