| Title |
1,8-Cineole (Eucalyptol) Mitigates Inflammation in Amyloid Beta Toxicated PC12 Cells: Relevance to Alzheimer’s Disease
|
|---|---|
| Published in |
Neurochemical Research, December 2013
|
| DOI | 10.1007/s11064-013-1231-9 |
| Pubmed ID | |
| Authors |
Andleeb Khan, Kumar Vaibhav, Hayate Javed, Rizwana Tabassum, Md. Ejaz Ahmed, Mohd. Moshahid Khan, M. Badruzzaman Khan, Pallavi Shrivastava, Farah Islam, M. Saeed Siddiqui, M. M. Safhi, Fakhrul Islam |
| Abstract |
Inflammatory process has a fundamental role in the pathogenesis of Alzheimer's disease and insoluble amyloid beta deposits and neurofibrillary tangles provide the obvious stimuli for inflammation. The present study demonstrate the effect of pretreatment of 1,8-cineole (Cin) on inflammation induced by Aβ(25-35) in differentiated PC12 cells. The cells were treated with Cin at different doses for 24 h and then replaced by media containing Aβ(25-35) for another 24 h. The cell viability was decreased in Aβ(25-35) treated cells which was significantly restored by Cin pretreatment. Cin successfully reduced the mitochondrial membrane potential, ROS and NO levels in Aβ(25-35) treated cells. Cin also lowered the levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in Aβ(25-35) treated cells. Moreover, Cin also succeeded in lowering the expression of NOS-2, COX-2 and NF-κB. This study suggests the protective effects of Cin on inflammation and provides additional evidence for its potential beneficial use in therapy as an anti-inflammatory agent in neurodegenerative disease. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Unknown | 95 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 17% |
| Student > Master | 11 | 11% |
| Student > Bachelor | 9 | 9% |
| Researcher | 8 | 8% |
| Lecturer | 6 | 6% |
| Other | 20 | 21% |
| Unknown | 26 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 17% |
| Biochemistry, Genetics and Molecular Biology | 11 | 11% |
| Agricultural and Biological Sciences | 9 | 9% |
| Medicine and Dentistry | 8 | 8% |
| Chemistry | 6 | 6% |
| Other | 14 | 15% |
| Unknown | 32 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2023.
All research outputs
#2,975,930
of 25,481,734 outputs
Outputs from Neurochemical Research
#94
of 2,267 outputs
Outputs of similar age
#32,946
of 319,249 outputs
Outputs of similar age from Neurochemical Research
#3
of 17 outputs
Altmetric has tracked 25,481,734 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,267 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.