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Mendeley readers
Attention Score in Context
| Title |
BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
|
|---|---|
| Published in |
Neurobiology of Aging, June 2013
|
| DOI | 10.1016/j.neurobiolaging.2013.05.006 |
| Pubmed ID | |
| Authors |
Yen Ying Lim, Victor L. Villemagne, Simon M. Laws, David Ames, Robert H. Pietrzak, Kathryn A. Ellis, Karra D. Harrington, Pierrick Bourgeat, Olivier Salvado, David Darby, Peter J. Snyder, Ashley I. Bush, Ralph N. Martins, Colin L. Masters, Christopher C. Rowe, Pradeep J. Nathan, Paul Maruff, Biomarkers and Lifestyle Research Group Australian Imaging |
| Abstract |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment. We aimed to determine the relationship between BDNF Val66Met and beta-amyloid (Aβ) on cognitive decline, hippocampal atrophy, and Aβ accumulation over 36 months in 165 healthy adults enrolled in the Australian Imaging, Biomarkers and Lifestyle study. In healthy adults with high Aβ, Met carriers showed significant and moderate-to-large declines in episodic memory, executive function, and language, and greater hippocampal atrophy over 36 months, compared with Val/Val homozygotes. BDNF Val66Met was not found to be related to rates of change in cognition or hippocampal volume in healthy adults with low Aβ. BDNF Val66Met did not relate to the amount of Aβ or to the rate of Aβ accumulation in either group. High Aβ levels coupled with Met carriage may be useful prognostic markers of accelerated cognitive decline and hippocampal degeneration in individuals in the preclinical stage of AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 196 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Israel | 1 | <1% |
| Greece | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 189 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 19% |
| Researcher | 30 | 15% |
| Student > Bachelor | 24 | 12% |
| Student > Master | 16 | 8% |
| Student > Doctoral Student | 15 | 8% |
| Other | 46 | 23% |
| Unknown | 28 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 18% |
| Neuroscience | 33 | 17% |
| Psychology | 31 | 16% |
| Agricultural and Biological Sciences | 15 | 8% |
| Biochemistry, Genetics and Molecular Biology | 8 | 4% |
| Other | 32 | 16% |
| Unknown | 41 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#1,964,496
of 25,373,627 outputs
Outputs from Neurobiology of Aging
#341
of 4,418 outputs
Outputs of similar age
#16,521
of 209,791 outputs
Outputs of similar age from Neurobiology of Aging
#7
of 41 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,418 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,791 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.