Title |
Genome wide mapping of Foxo1 binding-sites in murine T lymphocytes
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Published in |
Data in Brief, August 2014
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DOI | 10.1016/j.gdata.2014.08.006 |
Pubmed ID | |
Authors |
Will Liao, Weiming Ouyang, Michael Q. Zhang, Ming O. Li |
Abstract |
The Forkhead box O (Foxo) family of transcription factors has a critical role in controlling the development, differentiation, and function of T cells. However, the direct target genes of Foxo transcription factors in T cells have not been well characterized. In this study, we focused on mapping the genome wide Foxo1-binding sites in naïve CD4(+) T cells, CD8(+) T cells, and Foxp3(+) regulatory T (Treg) cells. By using chromatin immunoprecipitation coupled with deep sequencing (ChIP-Seq), we identified Foxo1 binding sites that were shared among or specific to the three T cell populations. Here we describe the experiments, quality controls, as well as the deep sequencing data. Part of the data analysis has been published by Ouyang W et al. in Nature 2012[1] and Kim MV et al. in Immunity 2013[2], and the associated data set were uploaded to NCBI Gene Expression Omnibus. |
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Mendeley readers
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