| Title |
Mice with heterozygous deficiency of manganese superoxide dismutase (SOD2) have a skin immune system with features of “inflamm-aging”
|
|---|---|
| Published in |
Archives of Dermatological Research, July 2013
|
| DOI | 10.1007/s00403-013-1389-7 |
| Pubmed ID | |
| Authors |
J. Scheurmann, N. Treiber, C. Weber, A. C. Renkl, D. Frenzel, F. Trenz-Buback, A. Rueß, G. Schulz, K. Scharffetter-Kochanek, J. M. Weiss |
| Abstract |
Dendritic cells (DC) are central in regulating skin immunity. Immunosenescence is associated with a chronic inflammatory state. Little is known about the contribution of DC to "inflamm-aging". When determining langerhans cell (LC) numbers, we found a 60 % reduction of LC in aged epidermis. Reactive oxygen species(ROS) are linked with aging. The mitochondrial manganese superoxide dismutase (SOD2) is in the first line of antioxidant defense. We investigated the function of DC from SOD2 heterozygous mice (SOD2+/-) and found that at 4 months of age LC numbers are not altered, but activated LC have impaired expression of MHC-II and CD44. Immature SOD2+/- DC produced increased proinflammatory IL-6 and chemokines CXCL1 and CXCL2. Upon challenge SOD2+/- DC accumulated ROS. When activating SOD2+/- DC by LPS they less efficiently upregulated MHC-II, CD86 and CD44. Surprisingly, in vivo contact hypersensitivity (CHS) was enhanced in SOD2+/- mice although SOD2+/- DC were less potent in stimulating wt T cells. However, SOD2+/- T cells showed increased proliferation, even when stimulated with SOD2+/- DC, possibly explaining the increased CHS. Our findings suggest that SOD2 is a molecular candidate in the regulation of "inflamm-aging" conveying both immunosuppressive and proinflammatory signals through alteration of DC and T cell functions. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 4% |
| Ireland | 1 | 4% |
| Unknown | 24 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 27% |
| Student > Ph. D. Student | 6 | 23% |
| Student > Bachelor | 2 | 8% |
| Professor | 2 | 8% |
| Professor > Associate Professor | 2 | 8% |
| Other | 4 | 15% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 31% |
| Agricultural and Biological Sciences | 7 | 27% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Neuroscience | 2 | 8% |
| Immunology and Microbiology | 2 | 8% |
| Other | 1 | 4% |
| Unknown | 3 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2014.
All research outputs
#20,239,689
of 22,766,595 outputs
Outputs from Archives of Dermatological Research
#1,190
of 1,323 outputs
Outputs of similar age
#170,271
of 194,067 outputs
Outputs of similar age from Archives of Dermatological Research
#13
of 14 outputs
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