Title |
Using skin for drug delivery and diagnosis in the critically ill
|
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Published in |
Advanced Drug Delivery Reviews, October 2014
|
DOI | 10.1016/j.addr.2014.10.004 |
Pubmed ID | |
Authors |
Xin Liu, Peter Kruger, Howard Maibach, Paul B. Colditz, Michael S. Roberts |
Abstract |
Skin offers easy access, convenience and non-invasiveness for drug delivery and diagnosis. In principle, these advantages of skin appear to be attractive for critically ill patients given potential difficulties that may be associated with oral and parenteral access in these patients. However, the profound changes in skin physiology that can be seen in these patients provide a challenge to reliably deliver drugs or provide diagnostic information. Drug delivery through skin may be used to manage burn injury, wounds, infection, trauma and the multisystem complications that rise from these conditions. Local anaesthetics and analgesics can be delivered through skin and may have wide application in critically ill patients. To ensure accurate information, diagnostic tools require validation in the critically ill patient population as information from other patient populations may not be applicable. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
India | 2 | 1% |
Australia | 1 | <1% |
Unknown | 155 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 36 | 23% |
Student > Ph. D. Student | 24 | 15% |
Student > Bachelor | 18 | 11% |
Researcher | 10 | 6% |
Student > Doctoral Student | 9 | 6% |
Other | 18 | 11% |
Unknown | 45 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 34 | 21% |
Medicine and Dentistry | 20 | 13% |
Chemistry | 11 | 7% |
Engineering | 9 | 6% |
Agricultural and Biological Sciences | 7 | 4% |
Other | 28 | 18% |
Unknown | 51 | 32% |