Title |
Chromosomal disorders: estimating baseline birth prevalence and pregnancy outcomes worldwide
|
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Published in |
Journal of Community Genetics, September 2017
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DOI | 10.1007/s12687-017-0336-2 |
Pubmed ID | |
Authors |
Sowmiya Moorthie, Hannah Blencowe, Matthew W. Darlison, Stephen Gibbons, Joy E. Lawn, Pierpaolo Mastroiacovo, Joan K. Morris, Bernadette Modell, Congenital Disorders Expert Group |
Abstract |
Chromosomal disorders, of which Down syndrome is the most common, can cause multi-domain disability. In addition, compared to the general population, there is a higher frequency of death before the age of five. In many settings, large gaps in data availability have hampered policy-making, programme priorities and resource allocation for these important conditions. We have developed methods, which overcome this lack of data and allow estimation of the burden of affected pregnancies and their outcomes in different settings worldwide. For example, the methods include a simple equation relating the percentage of mothers 35 and over to Down syndrome birth prevalence. The results obtained provide a starting point for consideration of services that can be implemented for the care and prevention of these disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Uruguay | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Members of the public | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 99 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 16 | 16% |
Student > Master | 12 | 12% |
Researcher | 11 | 11% |
Student > Doctoral Student | 8 | 8% |
Student > Ph. D. Student | 6 | 6% |
Other | 15 | 15% |
Unknown | 31 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 26% |
Biochemistry, Genetics and Molecular Biology | 15 | 15% |
Nursing and Health Professions | 7 | 7% |
Psychology | 4 | 4% |
Agricultural and Biological Sciences | 3 | 3% |
Other | 11 | 11% |
Unknown | 33 | 33% |