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Pathological consequences of systemic measles virus infection

Overview of attention for article published in The Journal of Pathology, December 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
13 X users
wikipedia
7 Wikipedia pages
q&a
1 Q&A thread

Citations

dimensions_citation
67 Dimensions

Readers on

mendeley
157 Mendeley
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Title
Pathological consequences of systemic measles virus infection
Published in
The Journal of Pathology, December 2014
DOI 10.1002/path.4457
Pubmed ID
Authors

Martin Ludlow, Stephen McQuaid, Dan Milner, Rik L de Swart, W Paul Duprex

Abstract

The identification of poliovirus receptor like 4 (PVRL4) as the second natural receptor for measles virus (MV) has closed a major gap in our understanding of measles pathogenesis and explains how this predominantly lymphotropic virus breaks through epithelial barriers to transmit to a susceptible host. Advances in the development of wild-type, recombinant MVs which express fluorescent proteins making infected cells readily detectable in living tissues and animals, has also added novel insights into this important and highly transmissible human disease. Thus it is timely to review how these advances have provided new insights into MV infection of immune, epithelial and neural cells. This demands access to primate samples which help us understand the early and acute stages of the disease which are challenging to dissect due to the mild/self-limiting nature of the infection. It also requires well-characterized and rather rare human tissue samples from patients who succumb to neurological sequelae to help study the consequences of the long term persistence of this RNA virus in vivo. Collectively, these studies have provided unique insights into how the use of two different cellular receptors, CD150 and PVRL4, governs the in vivo tissue specific temporal patterns of virus spread and resulting pathological lesions. Analysis of tissue samples has also demonstrated the importance of differing mechanisms of virus cell-to-cell spread within lymphoid, epithelial and neural tissues in the dissemination of MV during acute and long-term persistent infections. Given the incentive to globally eradicate MV and the inevitable question as to whether or not vaccination should cease in light of the presence of closely related morbilliviruses, a thorough understanding of measles pathological lesions is essential.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Germany 1 <1%
Unknown 155 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 34 22%
Student > Bachelor 26 17%
Researcher 13 8%
Student > Ph. D. Student 11 7%
Student > Doctoral Student 9 6%
Other 34 22%
Unknown 30 19%
Readers by discipline Count As %
Medicine and Dentistry 36 23%
Agricultural and Biological Sciences 22 14%
Biochemistry, Genetics and Molecular Biology 19 12%
Immunology and Microbiology 13 8%
Nursing and Health Professions 11 7%
Other 15 10%
Unknown 41 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2023.
All research outputs
#1,326,167
of 25,591,967 outputs
Outputs from The Journal of Pathology
#77
of 3,387 outputs
Outputs of similar age
#17,222
of 369,354 outputs
Outputs of similar age from The Journal of Pathology
#6
of 60 outputs
Altmetric has tracked 25,591,967 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,387 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,354 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.