Title |
Fructose ingestion acutely stimulates circulating FGF21 levels in humans
|
---|---|
Published in |
Molecular Metabolism, October 2014
|
DOI | 10.1016/j.molmet.2014.09.008 |
Pubmed ID | |
Authors |
Jody R. Dushay, Elena Toschi, Emilie K. Mitten, Ffolliott M. Fisher, Mark A. Herman, Eleftheria Maratos-Flier |
Abstract |
Fibroblast growth factor 21 (FGF21) is a hormone with pleiotropic metabolic activities which, in rodents, is robustly regulated by fasting and ketogenic diets. In contrast, similar dietary interventions have either no or minimal effects on circulating FGF21 in humans. Moreover, no intervention or dietary challenge has been shown to acutely stimulate circulating FGF21 in either humans or animals. Recent animal data suggest that the transcription factor Carbohydrate Responsive-Element Binding Protein (ChREBP) stimulates hepatic FGF21 expression and that fructose may activate hepatic ChREBP more robustly than glucose. Here, we examined whether fructose ingestion can acutely stimulate FGF21 in humans. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 5 | 36% |
United Kingdom | 1 | 7% |
Japan | 1 | 7% |
Netherlands | 1 | 7% |
Comoros | 1 | 7% |
Unknown | 5 | 36% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 57% |
Practitioners (doctors, other healthcare professionals) | 3 | 21% |
Scientists | 3 | 21% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 1% |
United States | 2 | 1% |
Switzerland | 1 | <1% |
Spain | 1 | <1% |
Sweden | 1 | <1% |
Unknown | 176 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 33 | 18% |
Student > Master | 22 | 12% |
Student > Ph. D. Student | 20 | 11% |
Student > Bachelor | 18 | 10% |
Other | 11 | 6% |
Other | 37 | 20% |
Unknown | 42 | 23% |
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---|---|---|
Medicine and Dentistry | 47 | 26% |
Biochemistry, Genetics and Molecular Biology | 32 | 17% |
Agricultural and Biological Sciences | 23 | 13% |
Neuroscience | 7 | 4% |
Nursing and Health Professions | 5 | 3% |
Other | 19 | 10% |
Unknown | 50 | 27% |