Title |
Management of AL amyloidosis
|
---|---|
Published in |
Internal Medicine Journal, April 2015
|
DOI | 10.1111/imj.12566 |
Pubmed ID | |
Authors |
N. Weber, P. Mollee, B. Augustson, R. Brown, L. Catley, J. Gibson, S. Harrison, P. J. Ho, N. Horvath, W. Jaksic, D. Joshua, H. Quach, A. W. Roberts, A. Spencer, J. Szer, D. Talaulikar, B. To, A. Zannettino, H. M. Prince |
Abstract |
Systemic light chain (AL) amyloidosis is a plasma cell dyscrasia with a characteristic clinical phenotype caused by multiorgan deposition of an amyloidogenic monoclonal protein. This condition poses a unique management challenge due to the complexity of the clinical presentation and the narrow therapeutic window of available therapies. Improved appreciation of the need for risk stratification, standardised use of sensitive laboratory testing for monitoring disease response, vigilant supportive care and the availability of newer agents with more favourable toxicity profiles have contributed to the improvement in treatment-related mortality and overall survival seen over the past decade. Nonetheless, with respect to the optimal management approach, there is a paucity of high-level clinical evidence due to the rarity of the disease and enrolment in clinical trials is still the preferred approach where available. This review will summarise the Clinical Practice Guidelines on the Management of Systemic Light Chain (AL) Amyloidosis recently prepared by the Medical Scientific Advisory Group (MSAG) of the Myeloma Foundation of Australia. It is hoped that these Guidelines will assist clinicians in better understanding and optimizing the management of this difficult disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
United Kingdom | 1 | 20% |
Spain | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 18% |
Other | 5 | 10% |
Student > Master | 5 | 10% |
Student > Bachelor | 4 | 8% |
Professor | 3 | 6% |
Other | 13 | 25% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 45% |
Agricultural and Biological Sciences | 5 | 10% |
Nursing and Health Professions | 3 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 6 | 12% |
Unknown | 12 | 24% |