| Title |
Regulation of Neurotransmitter Release by Amyloid Precursor Protein Through Synapsin Phosphorylation
|
|---|---|
| Published in |
Neurochemical Research, October 2017
|
| DOI | 10.1007/s11064-017-2418-2 |
| Pubmed ID | |
| Authors |
An Liu, Ying Zhang, Lifang Han, Guiqin He, Wei Xie, Zikai Zhou, Zhengping Jia |
| Abstract |
Abnormal processing of amyloid precursor protein (APP) and aggregation of the Aβ peptide are known to play a key role in the pathogenesis of Alzheimer disease, but the function of endogenous APP under normal physiological conditions remains poorly understood. In this study, we investigated presynaptic changes in APP knockout (KO) mice. We demonstrate that both sucrose-induced neurotransmission and synaptic depletion in response to high frequency stimulation are significantly enhanced in APP KO compared to wild type littermates. In addition, the level of phosphorylated forms of synapsins, but not total synapsins, is elevated in the KO mice. Furthermore, we show that the inhibition of L-type calcium channels normalizes phosphorylated synapsins and slows down the high frequency induced synaptic depletion in APP KO mice. These results suggest a new mechanism by which APP regulates synaptic vesicle dynamics through synapsin-dependent phosphorylation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 22% |
| Student > Ph. D. Student | 6 | 22% |
| Student > Bachelor | 4 | 15% |
| Lecturer | 1 | 4% |
| Other | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 6 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 22% |
| Biochemistry, Genetics and Molecular Biology | 3 | 11% |
| Agricultural and Biological Sciences | 3 | 11% |
| Computer Science | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 9 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2017.
All research outputs
#20,450,513
of 23,006,268 outputs
Outputs from Neurochemical Research
#1,700
of 2,106 outputs
Outputs of similar age
#285,350
of 327,202 outputs
Outputs of similar age from Neurochemical Research
#12
of 19 outputs
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