Title |
Engineering kidneys from simple cell suspensions: an exercise in self-organization
|
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Published in |
Pediatric Nephrology, August 2013
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DOI | 10.1007/s00467-013-2579-4 |
Pubmed ID | |
Authors |
Jamie A. Davies, C-Hong Chang |
Abstract |
Increasing numbers of people approaching and living with end-stage renal disease and failure of the supply of transplantable kidneys to keep pace has created an urgent need for alternative sources of new organs. One possibility is tissue engineering of new organs from stem cells. Adult kidneys are arguably too large and anatomically complex for direct construction, but engineering immature kidneys, transplanting them, and allowing them to mature within the host may be more feasible. In this review, we describe a technique that begins with a suspension of renogenic stem cells and promotes these cells' self-organization into organ rudiments very similar to foetal kidneys, with a collecting duct tree, nephrons, corticomedullary zonation and extended loops of Henle. The engineered rudiments vascularize when transplanted to appropriate vessel-rich sites in bird eggs or adult animals, and show preliminary evidence for physiological function. We hope that this approach might one day be the basis of a clinically useful technique for renal replacement therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 2% |
Brazil | 1 | 2% |
United Kingdom | 1 | 2% |
Slovenia | 1 | 2% |
United States | 1 | 2% |
Unknown | 49 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 24% |
Student > Ph. D. Student | 10 | 19% |
Student > Bachelor | 9 | 17% |
Student > Master | 7 | 13% |
Professor | 3 | 6% |
Other | 7 | 13% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 17 | 31% |
Medicine and Dentistry | 10 | 19% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Nursing and Health Professions | 3 | 6% |
Engineering | 3 | 6% |
Other | 8 | 15% |
Unknown | 6 | 11% |