| Title |
Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, October 2014
|
| DOI | 10.1007/s11010-014-2236-7 |
| Pubmed ID | |
| Authors |
Mrittika Chattopadhyay, Vineet Kumar Khemka, Gargi Chatterjee, Anirban Ganguly, Satinath Mukhopadhyay, Sasanka Chakrabarti |
| Abstract |
Oxidative stress in the insulin target tissues has been implicated in the pathophysiology of type 2 diabetes. The study has examined the oxidative stress parameters in the mitochondria of subcutaneous white adipose tissue from obese and non-obese subjects with or without type 2 diabetes. An accumulation of protein carbonyls, fluorescent lipid peroxidation products, and malondialdehyde occurs in the adipose tissue mitochondria of obese type 2 diabetic, non-diabetic obese, and non-obese diabetic subjects with the maximum increase noticed in the obese type 2 diabetes patients and the minimum in non-obese type 2 diabetics. The mitochondria from obese type 2 diabetics, non-diabetic obese, and non-obese type 2 diabetics also produce significantly more reactive oxygen species (ROS) in vitro compared to those of controls, and apparently the mitochondrial ROS production rate in each group is proportional to the respective load of oxidative damage markers. Likewise, the mitochondrial antioxidant enzymes like superoxide dismutase and glutathione peroxidase show decreased activities most markedly in obese type 2 diabetes subjects and to a lesser degree in non-obese type 2 diabetes or non-diabetic obese subjects in comparison to control. The results imply that mitochondrial dysfunction with enhanced ROS production may contribute to the metabolic abnormality of adipose tissue in obesity and diabetes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 109 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 18% |
| Student > Ph. D. Student | 17 | 15% |
| Researcher | 16 | 15% |
| Student > Master | 10 | 9% |
| Student > Doctoral Student | 6 | 5% |
| Other | 17 | 15% |
| Unknown | 24 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 26% |
| Agricultural and Biological Sciences | 20 | 18% |
| Medicine and Dentistry | 13 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Business, Management and Accounting | 2 | 2% |
| Other | 11 | 10% |
| Unknown | 32 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2014.
All research outputs
#18,380,628
of 22,766,595 outputs
Outputs from Molecular and Cellular Biochemistry
#1,558
of 2,297 outputs
Outputs of similar age
#182,694
of 255,842 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#15
of 45 outputs
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So far Altmetric has tracked 2,297 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.