| Title |
Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease
|
|---|---|
| Published in |
Molecular Neurobiology, October 2014
|
| DOI | 10.1007/s12035-014-8908-1 |
| Pubmed ID | |
| Authors |
Liang Zhou, Hongfeng Wang, Haigang Ren, Qingsong Hu, Zheng Ying, Guanghui Wang |
| Abstract |
Poly-ubiquitinated protein aggregate formation is the most striking hallmark of various neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and prion disease. Mutations of many ubiquitin-associated proteins involved in the regulation of protein aggregation, such as SQSTM1/p62 (p62), parkin, and VCP, are closely linked to neurodegeneration. B-cell lymphoma 2 (Bcl-2) is a key regulator in autophagy, apoptosis, and mitochondria quality control in many cell types including neurons, and it plays important roles in the pathogenesis of neurodegenerative diseases mentioned above. Our previous work showed that Bcl-2 can directly bind to p62, and here we report that Bcl-2 directly interacts with the N-terminus of p62, but not the C-terminus (UBA domain). Interestingly and importantly, Bcl-2 affects the affinity of p62 to poly-ubiquitin chains and suppresses the aggregation of poly-ubiquitinated proteins such as mutant huntingtin associated with Huntington's disease. Our study reveals a role of Bcl-2 that involves in the regulation of misfolded proteins. |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Chile | 1 | 2% |
| Unknown | 46 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 21% |
| Student > Master | 8 | 17% |
| Researcher | 6 | 13% |
| Student > Postgraduate | 6 | 13% |
| Student > Ph. D. Student | 5 | 10% |
| Other | 8 | 17% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 27% |
| Agricultural and Biological Sciences | 11 | 23% |
| Medicine and Dentistry | 6 | 13% |
| Neuroscience | 6 | 13% |
| Psychology | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 4 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2014.
All research outputs
#20,239,689
of 22,766,595 outputs
Outputs from Molecular Neurobiology
#2,778
of 3,441 outputs
Outputs of similar age
#213,545
of 255,842 outputs
Outputs of similar age from Molecular Neurobiology
#45
of 77 outputs
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