| Title |
Commensal microbiota regulates T cell fate decision in the gut
|
|---|---|
| Published in |
Seminars in Immunopathology, October 2014
|
| DOI | 10.1007/s00281-014-0455-3 |
| Pubmed ID | |
| Authors |
Yukihiro Furusawa, Yuuki Obata, Koji Hase |
| Abstract |
Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous bacteria (SFB) facilitate the development of TH17 cells in the small intestine. The 17 strains within clusters IV, XIVa, and XVIII of Clostridiales found in human feces can also induce the differentiation and expansion of Treg cells in the colon. Thus, the regulation of TH cell differentiation by commensal bacteria is evident; however, the molecular mechanisms underlying these processes remain uncertain. Recent studies have demonstrated that bacterial components, as well as their metabolites, play a central role in regulating TH cell development. Furthermore, these metabolites can elicit changes in histone posttranslational modification to modify the expression of critical regulators of T cell fate. In this review, we discuss the mechanisms and biological significance of microbiota-dependent TH differentiation. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| France | 1 | <1% |
| Norway | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 119 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 23% |
| Student > Ph. D. Student | 19 | 15% |
| Student > Bachelor | 19 | 15% |
| Student > Master | 18 | 15% |
| Student > Doctoral Student | 8 | 6% |
| Other | 18 | 15% |
| Unknown | 13 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 24% |
| Medicine and Dentistry | 28 | 23% |
| Immunology and Microbiology | 22 | 18% |
| Biochemistry, Genetics and Molecular Biology | 15 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 10 | 8% |
| Unknown | 17 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2015.
All research outputs
#17,489,487
of 25,654,806 outputs
Outputs from Seminars in Immunopathology
#554
of 722 outputs
Outputs of similar age
#162,043
of 268,668 outputs
Outputs of similar age from Seminars in Immunopathology
#10
of 18 outputs
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