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X Demographics
Mendeley readers
| Title |
Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro
|
|---|---|
| Published in |
Cell Chemical Biology, January 2014
|
| DOI | 10.1016/j.chembiol.2013.11.014 |
| Pubmed ID | |
| Authors |
Christina I. Schroeder, Joakim E. Swedberg, Jane M. Withka, K. Johan Rosengren, Muharrem Akcan, Daniel J. Clayton, Norelle L. Daly, Olivier Cheneval, Kris A. Borzilleri, Matt Griffor, Ingrid Stock, Barbara Colless, Phillip Walsh, Philip Sunderland, Allan Reyes, Robert Dullea, Mark Ammirati, Shenping Liu, Kim F. McClure, Meihua Tu, Samit K. Bhattacharya, Spiros Liras, David A. Price, David J. Craik |
| Abstract |
Disrupting the binding interaction between proprotein convertase (PCSK9) and the epidermal growth factor-like domain A (EGF-A domain) in the low-density lipoprotein receptor (LDL-R) is a promising strategy to promote LDL-R recycling and thereby lower circulating cholesterol levels. In this study, truncated 26 amino acid EGF-A analogs were designed and synthesized, and their structures were analyzed in solution and in complex with PCSK9. The most potent peptide had an increased binding affinity for PCSK9 (KD = 0.6 μM) compared with wild-type EGF-A (KD = 1.2 μM), and the ability to increase LDL-R recycling in the presence of PCSK9 in a cell-based assay. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 2 | 3% |
| Netherlands | 1 | 1% |
| United Kingdom | 1 | 1% |
| Unknown | 72 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 20% |
| Researcher | 14 | 18% |
| Student > Bachelor | 12 | 16% |
| Other | 7 | 9% |
| Student > Doctoral Student | 4 | 5% |
| Other | 11 | 14% |
| Unknown | 13 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 21% |
| Biochemistry, Genetics and Molecular Biology | 15 | 20% |
| Chemistry | 11 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
| Medicine and Dentistry | 4 | 5% |
| Other | 7 | 9% |
| Unknown | 17 | 22% |