Title |
Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation
|
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Published in |
The Journal of Immunology, November 2014
|
DOI | 10.4049/jimmunol.1402051 |
Pubmed ID | |
Authors |
Qifan Zhu, Si Ming Man, Prajwal Gurung, Zhiping Liu, Peter Vogel, Mohamed Lamkanfi, Thirumala-Devi Kanneganti |
Abstract |
Stimulator of IFN genes (STING) is a cytoplasmic innate immune sensor for cyclic dinucleotides that also serves a dual role as an adaptor molecule for a number of intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and autoimmune diseases, its physiological role in cancer is unknown. In this study, we show that STING-deficient mice are highly susceptible to colitis-associated colorectal cancer. Colons of STING-deficient mice exhibit significant intestinal damage and overt proliferation during early stages of tumorigenesis. Moreover, STING-deficient mice fail to restrict activation of the NF-κB- and STAT3-signaling pathways, which leads to increased levels of the proinflammatory cytokines IL-6 and KC. Therefore, our results identified an unexpected and important role for STING in mediating protection against colorectal tumorigenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
France | 1 | <1% |
Austria | 1 | <1% |
Unknown | 109 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 33 | 29% |
Student > Ph. D. Student | 31 | 28% |
Student > Doctoral Student | 9 | 8% |
Student > Bachelor | 7 | 6% |
Student > Master | 5 | 4% |
Other | 10 | 9% |
Unknown | 17 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 21% |
Medicine and Dentistry | 21 | 19% |
Biochemistry, Genetics and Molecular Biology | 18 | 16% |
Immunology and Microbiology | 14 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 8 | 7% |
Unknown | 22 | 20% |